共价有机框架材料TpPa-NH_(2)-D-(-)-α-苯甘氨酸用作高效液相色谱手性固定相研究  

Covalent Organic Framework Material TpPa-NH_(2)-D-(-)-α-Phenylglycine as Chiral Stationary Phase for High Performance Liquid Chromatography

作　　者：陈政 禹紫云 段爱红[1] 刘华林 袁黎明[1] CHEN Zheng;YU Zi-yun;DUAN Ai-hong;LIU Hua-Lin;YUAN Li-ming(School of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming 650500,China)

机构地区：[1]云南师范大学化学化工学院,云南昆明650500

出　　处：《化学试剂》2023年第1期92-98,共7页Chemical Reagents

基　　金：国家自然科学基金资助项目(22174125)。

摘　　要：共价有机框架(COFs)是通过共价键连接多齿有机结构单元而形成的一类新兴的多孔晶体材料,其成分、结构和功能均具有可调性。由于对手性多孔材料需求的不断增加,且COFs材料拥有比表面积大、有序和永久的孔隙率等优点,COFs材料在不对称催化和分离领域越来越受到人们的重视。对映体之间通常因具有相类似的物理性质和化学性质,一直以来都是分离领域想要突破的难点。通过溶剂热法合成一种具有高结晶度和孔隙率以及在强酸和强碱中具有高化学稳定性的手性共价有机骨架(CCOFs)材料的手性衍生物TpPa-NH_(2)-D-(-)-α-苯甘氨酸。采用“网包法”制备TpPa-NH_(2)-D-(-)-α-苯甘氨酸手性固定相,并用其制备高效液相色谱手性柱,考察其对外消旋体拆分和苯系位置异构体的分离能力。TpPa-NH_(2)-D-(-)-α-苯甘氨酸色谱柱分开了11种手性化合物和7种苯系位置异构体,还具有较好的重现性,表明其分离效果良好。COFs are an emerging class of porous crystalline materials formed by covalently linking multidentate organic building blocks with tunable composition,structure,and function.Due to the increasing demand for chiral porous materials and the many advantages of COFs such as large specific surface area,and ordered and permanent porosity,COFs have attracted more and more attention in the field of asymmetric catalysis and separation.Enantiomers usually have similar physical and chemical properties,which has always been a difficult point in the separation field.In this paper,a CCOFs material TpPa-NH_(2)-D-(-)-α-phenylglycine with high crystallinity and porosity and high chemical stability in strong acids and bases was synthesized by the solvothermal method.TpPa-NH_(2)-D-(-)-α-phenylglycine chiral stationary phase was prepared by“net-encapsulation method”,and it was used to prepare high-performance liquid chromatography chiral column,and its racemate resolution and benzene series position were investigated Separation ability of isomers.The TpPa-NH_(2)-D-(-)-α-phenylglycine chromatographic column separated 11 chiral compounds and 7 benzene-based positional isomers with good reproducibility,indicating that the separation effect was well.

关 键 词：共价有机骨架 高效液相色谱 手性化合物 手性分离 手性固定相 

分 类 号：O657.7[理学—分析化学]