褪黑素与内源生物钟介导的哺乳动物季节性繁殖机理研究进展  

Research Progress on the Mechanism of Seasonal Reproduction in Mammals Mediated by Melatonin and Annual Clock

作　　者：赵淑琴 韩亚轩 鲁巨贵 杨榛 ZHAO Shuqin;HAN Yaxuan;LU Jugui;YANG Zhen(Basic Experimental Teaching Center,Gansu Agricultural University,Gansu Lanzhou 730070,China;College of Animal Science and Technology,Gansu Agricultural University,Gansu Lanzhou 730070,China;Agricultural and Rural Bureau of Gansu Province Lanzhou City Honggu District,Gansu Lanzhou 730070,China)

机构地区：[1]甘肃农业大学基础实验教学中心,甘肃兰州730070 [2]甘肃农业大学动物科学技术学院,甘肃兰州730070 [3]甘肃省兰州市红古区农业农村局,甘肃兰州730070

出　　处：《中国畜牧杂志》2022年第11期65-72,共8页Chinese Journal of Animal Science

基　　金：甘肃省教育厅青年博士基金项目(2021QB-034)。

摘　　要：哺乳动物的季节性繁殖是长期进化过程中形成的年度节律。视网膜感知光照,将信号传递给下丘脑的视交叉上核(Suprachiasmatic Nucleus,SCN)引起生物钟振荡。此时松果体也响应光信号,引起褪黑素分泌的变化。生物钟和褪黑素共同参与下丘脑-垂体-性腺轴(Hypothalamic-Pituitary-Gonadal Axis,HPGA)的生殖调控,完成动物的季节性繁殖。本文综述了褪黑素、生物钟在季节性繁殖动物调控中的作用机制,以及褪黑素与生物钟基因之间的直接交互作用和间接交互作用,为进一步完善哺乳动物的季节性繁殖机制提供研究基础。The seasonal reproduction of mammals is an annual rhythm coused by long-term evolution. The retina perceives light and transmits the signal to the suprachiasmatic nucleus(SCN) of the hypothalamus to cause the circadian clock oscillate.Meanwhile, the pineal gland was also stimulated by light signals, causing changes in melatonin secretion. Both circadian and melatonin participate in the reproductive regulation of the hypothalamic-pituitary-gonadal axis(HPGA) to complete the animal seasonal reproductions. This article reviews the regulation mechanism of melatonin and circadian clock influencing the seasonal breeding animals, including the direct and indirect interaction between melatonin and circadian clock genes. It provides a comprehensive knowledge for further improving the seasonal reproduction mechanism of mammals.

关 键 词：褪黑素 生物钟 季节性繁殖动物 生殖调控 

分 类 号：Q492[生物学—生理学]