Pathogenesis of anti-melanoma differentiation-associated gene-5(MDA5)dermatomyositis  

作　　者：Chenghua Weng Zhichun Liu 

机构地区：[1]Department of Rheumatology and Immunology,The Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215000,China

出　　处：《Chinese Medical Journal》2022年第18期2188-2190,共3页中华医学杂志（英文版）

基　　金：supported by grants from the Jiangsu Provincial Key R&D Program(Social Development)(No.BE2019663);the Suzhou Health and Key Talent Project(No.GSWS2019011).

摘　　要：Dermatomyositis(DM)is an idiopathic inflammatory myopathy,with typical cutaneous manifestations and muscle lesions,usually involving multiple organs.Patients with antimelanoma differentiation-associated gene-5(MDA5)DM usually present with clinical amyopathic DM(CADM),which is characterized by a series of unique skin and systemic manifestations,including skin ulcer and interstitial lung disease(ILD).Among them,ILD is the most common complication of anti-MDA5 DM,and in some cases,it can develop into rapidly progressive ILD(RP-ILD).^([1,2])

关 键 词：MDA5 ORGANS LESIONS 

分 类 号：R593.26[医药卫生—内科学]