Correlation between IL-33/sST2 signaling pathway and patients with essential hypertensive left ventricular hypertrophy  

作　　者：XING Bu-dian WEI Ting LU Yuan-yuan LENG Jun-jie KANG Pin-fang WANG Hong-ju ZHANG Ning-ru 

机构地区：[1]Department of Cardiovascular Medicine,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233000,China

出　　处：《Journal of Hainan Medical University》2022年第21期22-26,共5页海南医学院学报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81970313);Anhui Province Science and Technology Project(No.1804h08020246)。

摘　　要：Objective:To detect the levels of interleukin-33(IL-33)and soluble ST2(sST2)in peripheral blood of patients with essential hypertensive left ventricular hypertrophy,and to discusstheir correlation with patients with essential hypertensive left ventricular hypertrophy was further discussed.Methods:A total of 220 patients with essential hypertension treated in the Department of Cardiovascular Medicine of the First Affiliated Hospital of Bengbu Medical College were enrolled as the experimental group.According to left ventricular mass index(LVMI),patients with essential hypertension were divided into the non-left ventricular hypertrophy group(NLVH,n=108 cases)and the left ventricular hypertrophy group(LVH,n=112 cases).We used ELISA to detect the serum levels of IL-33 and sST2,the expression levels of IL-33 in peripheral blood lymphocytes of the NLVH group and the LVH group(60 cases each)were detected by Western blot,and the relationship between IL-33 and LVMI,a marker of left ventricular hypertrophic condition,was analyzed by Pearson.The relationship between IL-33,sST2 and left ventricular hypertrophy in essential hypertension was studied.Results:Compared with the NLVH group,the expression levels of IL-33 and sST2 in the LVH group were significantly increased.The results of Western blot showed that the expression level of IL-33 in the LVH group(1.07±0.08)was higher than that in the NLVH group(0.63±0.05)(P<0.05).Pearson correlation analysis showed that IL-33 was positively correlated with LVMI,sST2 was positively correlated with LVMI.Conclusion:The levels of IL-33 and sST2 in serum and the expression levels of IL-33 protein in peripheral blood lymphocytes are significantly increased in patients with hypertensive left ventricular hypertrophy,and the occurrence and development of essential hypertensive left ventricular hypertrophy may be related to IL-33 and sST2.

关 键 词：Essential hypertension IL-33 sST2 Left ventricular hypertrophy Left ventricular mass index 

分 类 号：R544.11[医药卫生—心血管疾病]