间充质干细胞在女性生殖医学领域的研究进展  

Research progress of mesenchymal stem cells in female reproductive medicine

作　　者：赵静 王含必[2] 邓成艳[2] Zhao Jing;Wang Hanbi;Deng Chengyan(Department of Reproductive Medicine,Fuyang People′s Hospital,Fuyang 236000,China)

机构地区：[1]安徽省阜阳市人民医院生殖医学科,阜阳236000 [2]中国医学科学院北京协和医学院北京协和医院妇产科,国家妇产疾病临床研究中心,疑难重症及罕见病国家重点实验室,北京100730

出　　处：《中华预防医学杂志》2022年第12期1709-1715,共7页Chinese Journal of Preventive Medicine

基　　金：中华医学会临床医学科研专项基金干细胞基础研究(19020020781);中国医学科学院中央级公益性科研院所基本科研业务费专项资金(2021-PT320-001)。

摘　　要：干细胞作为医学研究的热点已久,其在组织修复、疾病的诊断和治疗方面有着独特的优势。随着再生医学的发展,干细胞在生殖医学领域的研究和应用也越来越广泛,如改善卵巢功能、子宫内膜损伤后修复等。这些研究主要是通过利用各种来源的间充质干细胞(mesenchymal stem cells,MSCs)来实现的。但是,干细胞的应用同时也面临着细胞保留率低、医学伦理等问题,本文着重阐述间充质干细胞(不涉及胚胎干细胞)在女性生殖医学领域的研究进展及临床应用。Stem cells have been a hot spot in medical research for a long time and have unique advantages in tissue repair,diagnosis and treatment of diseases.With the development of regenerative medicine,stem cells have been widely studied and applied in reproductive medicine,such as improving ovarian function and repairing endometrial damage.These efforts are achieved primarily through the use of mesenchymal stem cells(MSCs)from a variety of sources.However,the application of stem cells also faces problems such as low cell retention rate and medical ethics.This article focuses on the research progress and clinical application of MSCs(not involving embryonic stem cells)in the field of female reproductive medicine.

关 键 词：干细胞 生殖医学 早发性卵巢功能不全 卵巢早衰 宫腔粘连 

分 类 号：R71[医药卫生—妇产科学]