白花败酱草的化学成分、药理活性及质量控制研究进展  

Research progress on chemical constituents,pharmacological activities,and quality control of Patrinia villosa

作　　者：范宇 沙冬梅 沙马里牛 兰建龙 海来约布 曲别军长 阎新佳 刘圆 FAN Yu;SHA Dong-mei;SHA Ma-li-niu;LAN Jian-long;HAI Lai-yue-bu;QU Bie-jun-zhang;YAN Xin-jia;LIU Yuan(Instilute of Qinghai-Tibetan Plateau,Southucest Minzu University,Chengdu 610041,China;Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Comission of the People's Republic of China,Chengdu 610225.China;Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Uiliation Technology Engineering Laboratory,Chengdu 610225,China;Institute of Pharmaceutical Analysis,College of Pharmacy,Jinan University,Guangzhou 510632,China)

机构地区：[1]西南民族大学青藏高原研究院,四川成都610041 [2]青藏高原民族药用资源保护与利用国家民委重点实验室,四川成都610225 [3]四川省羌彝药用资源保护与利用技术工程实验,四川成都610225 [4]暨南大学药学院药物分析研究中心,广东广州510632

出　　处：《中国中药杂志》2022年第22期6005-6019,共15页China Journal of Chinese Materia Medica

基　　金：国家重点研发计划项目(2018YFC1708005);四川省科技计划项目(2021YFS0043);2021年国家民委领军人才支持计划;中央高校基本科研业务费校级创新团队专项项目(ZYN2022067)。

摘　　要：白花败酱草Patrinia villosa在清热解毒、消痈排脓的功用上是一味民间传统、运用广泛的中草药材,含多种氨基酸、维生素、可溶性糖等,营养价值丰富,在我国作为传统野菜食用已有两千年历史。1973年日本学者从日本产白花败酱草中分离出3种环烯醚萜类成分后,截至目前,已从中分离出黄酮类、环烯醚萜类、有机酸类、三萜类、苯丙素类、甾体等多种化学成分,具有抗氧化、抗肿瘤、抗腹泻、抗菌、镇静、保肝等药理作用;研究表明,其黄酮类、皂苷类、苯丙素类、三萜类化合物等为其重要药理活性基础物质。由于历代医药古籍记载模糊、各地用药习惯不同导致药材使用混乱,药材质量无法控制,目前已有研究者采用黄酮类、有机酸类、苯丙素类、三萜皂苷类等化合物对其进行质量控制研究。该研究依据前人对白花败酱草的研究成果,依次从化学成分、药理活性及质量控制方面进行归纳与概括,进一步为临床用药安全有效提供依据,为后续实验研究奠定基础。Patrinia villosa, regarding its functions in clearing heat and detoxification and eliminating carbuncles and pus, is widely used as a traditional medicinal herb that contains rich nutrition and substances such as various amino acids, vitamins, and soluble su-gar, and it is also an edible wild herb in Chinese folk tradition for 2 000 years. In 1973, Japanese scholars firstly separated three iridoids from Japanese P. villosa, and by 2021, chemical components such as flavonoids, iridoids, organic acids, triterpenoids, phenylpropanoids, and steroids have been found, which have multiple pharmacological effects, including antioxidant, antitumor, anti-diarrhea, antibacterial, sedative, and liver protection capabilities. Studies indicate that flavonoids, saponins, phenylpropanoids, and triterpenoids in P. villosa are vital substances for its pharmacological activities. However, the quality of this medicinal material cannot be controlled due to the unclear records in ancient books in the past dynasties and different drug use habits in different places, and thus its circulation is chaotic. At present, researchers have used flavonoids, organic acids, phenylpropanoids, triterpenoid saponins, and other compounds to conduct studies in this regard. Therefore, on the basis of the existing literature resources, we comprehensively summarize the chemical constituents, pharmacological activities, and quality control of P. villosa to further provide a reference for the safety and effectiveness of clinical drug use and lay a foundation for the follow-up experimental research.

关 键 词：白花败酱草 化学成分 药理活性 质量控制 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]