老年退行性心脏瓣膜病的相关危险因素分析  

Risk factors of senile degenerative valvular heart disease

作　　者：于文华[1] 刘玉娟[2] 于瑶[1] 刘佳[1] 王珊 胡松[1] 毛拥军[1] Yu Wenhua;Liu Yujuan;Yu Yao;Liu Jia;Wang Shan;Hu Song;Mao Yongjun(Department of Geriatrics,the Affiliated Hospital of Qingdao University,Qingdao 266000 China;Department of Nutrition,Women and Children's Hospital Affiliated to Qingdao University,Qingdao 266000 China)

机构地区：[1]青岛大学附属医院老年医学科,青岛266000 [2]青岛大学附属妇女儿童医院营养科,青岛266000

出　　处：《中华老年医学杂志》2022年第12期1468-1472,共5页Chinese Journal of Geriatrics

摘　　要：目的探讨老年退行性心脏瓣膜病患者的临床特点及相关危险因素,为老年退行性心脏瓣膜病的早期预防干预提供临床依据。方法收集2022年1月至2022年6月于我院住院的1568例≥60岁老年患者的临床资料,比较退行性心脏瓣膜病组和非退行性心脏瓣膜病组患者的临床特点并分析其危险因素。结果年龄(每增加10岁)(OR=2.107,95%CI=1.518~2.924)、血钙(OR=8.934,95%CI=2.023~39.447)、总胆固醇(OR=1.167,95%CI=1.044~1.304)、女性(OR=2.098,95%CI=1.305~3.374)、平均血小板体积(MPV)降低(OR=0.818,95%CI=0.682~0.981)是影响老年退行性心脏瓣膜病发生的独立危险因素(P<0.05)。两两比较显示:不同钙化程度均与年龄相关(P<0.05);无钙化组载脂蛋白A、尿酸、血磷、游离三碘甲状腺原氨酸与对照组相比差异有统计学意义(P<0.05);中度钙化组二尖瓣舒张早期血流流速峰值与二尖瓣环舒张早期运动速度峰值比值(E/e′)、N端脑钠肽前体与对照组相比有统计学意义(P<0.05);无钙化组和轻度钙化组总胆固醇与对照组相比有统计学意义(P<0.05)。结论年龄、血钙、总胆固醇、女性、MPV降低是老年退行性心脏瓣膜病的独立危险因素。Objective To explore the clinical characteristics and related risk factors of senile degenerative valvular heart disease(SDHVD),and to provide clinical basis for early prevention intervention of SDHVD.Methods Clinical data of 1568 elderly patients≥60 years old hospitalized in our hospital from January 2022 to June 2022 were collected to compare the clinical characteristics and analyze the risk factors of patients in the degenerative heart valve disease group and the non-degenerative heart valve disease group.Results Age(per 10-year increase)(OR=2.107,95%CI=1.518-2.924),blood calcium(OR=8.934,95%CI=2.023-39.447),total cholesterol(OR=1.167,95%CI=1.044-1.304),female(OR=2.098,95%CI=1.305-3.374),and reduced mean platelet volume(MPV)(OR=0.818,95%CI=0.682-0.981)were independent risk factors for the development of SDHVD(P<0.05).Post hoc two-by-two comparisons showed that different degrees of calcification were associated with age(P<0.05);apoA,UA,P,and FT3 were statistically significant in the no-calcification group compared with the control group(P<0.05);E/e′,PASP,and NT-ProBNP were statistically significant in the moderate calcification group compared with the control group(P<0.05);TC was statistically significant in the no-calcification and mild calcification groups compared with the control group There was statistical significance(P<0.05)compared with the control group.Conclusions Age,blood calcium,total cholesterol,female,and reduced MPV are independent risk factors for SDHVD.

关 键 词：心脏瓣膜疾病 年龄因素 危险因素 

分 类 号：R542.5[医药卫生—心血管疾病]