效应面法优化金蒲菊清热利湿颗粒成型工艺  

Optimization of molding process of Jinpuju Qingrelishi Granules by Response Surface Methodology

作　　者：陈卫卫 黄金成 黎金享 覃营 李雨洋 刘相岑 谭兴贵 Chen Weiwei;Huang Jincheng;Li Jinxiang;Qin Ying;Li Yuyang;Liu Xiangcen;Tan Xinggui(College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China;School of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410000,China)

机构地区：[1]广西中医药大学药学院,南宁530200 [2]湖南中医药大学中医学院,长沙410000

出　　处：《国际中医中药杂志》2022年第11期1273-1277,共5页International Journal of Traditional Chinese Medicine

基　　金：广西中医药大学2019年自治区级大学生创新创业训练计划项目(201910600074);广西壮瑶药重点实验室项目(桂科基字[2014]32号);壮瑶药协同创新中心项目(桂教科研[2013]20号);广西重点学科(壮药学)项目(桂教科研[2013]16号);广西第八批特聘专家项目(桂人才通字[2019]13号);第一批“港澳台英才”入桂计划项目壮瑶药质量标准现代化研究(桂科智字[2019]42号);广西一流学科建设项目广西中医药大学中药学科项目(桂教科研[2018]12号);广西一流学科中药学(民族药学)项目(桂教科研[2018]12号);广西壮瑶医药与医养结合人才小高地项目(中共广西区委厅发[2017]44号)。

摘　　要：目的优选金蒲菊清热利湿颗粒的最佳成型工艺。方法在单因素试验基础上,以清膏相对密度和稀释剂(糊精∶乳糖=2∶1)用量为考察因素,以成型率和休止角的总评"归一值"为评价指标,用效应面法优化金蒲菊清热利湿颗粒的最佳成型工艺。结果最佳成型工艺条件:清膏的相对密度为1.20(60℃),稀释剂用量为清膏的3倍。清膏与稀释剂混匀后制软材,过14目筛制粒,烘箱(55℃)干燥1 h,整粒,即得。3批验证试验颗粒剂的成型率分别为93.73%、93.03%、95.59%,归一值预测值为0.928,验证值为0.936,与预测值偏差为-0.86%。结论该成型工艺稳定可靠,重复性好,可为金葡菊清热利湿颗粒的后续研究提供参考依据。Objective To optimize the best molding process of Jinpuju Qingrelishi Granules.Methods Based on the single factor test,the relative density of clear ointment and the amount of diluent(dextrin∶lactose=2∶1)are used as investigating factors,and the overall evaluation of the molding rate and angle of repose overall desirability(OD)is used as the evaluation index.The effect surface method is used to optimize the best molding process of Jinpuju Qingrelishi Granules.Results The best molding process conditions:the relative density of the clear paste is 1.20(60℃)and the amount of diluent is 3 times that of the clear paste.After mixing the clear paste and diluent,make soft material,pass through a 14-mesh sieve to granulate,dry in an oven(55℃)for 1 hour,and sizing to obtain.The molding rates of the three batches of verification test granules were 93.73%,93.03%,95.59%,respectively,the predicted OD value was 0.928,the verification value was 0.936,and the deviation from the predicted value was-0.86%.Conclusion The molding process of this experiment is stable and reliable,with good repeatability,which can provide a reference for the follow-up research of Jinpuju Qingrelishi Granules.

关 键 词：颗粒剂 金蒲菊清热利湿颗粒 成型工艺 效应面法 中药工艺改进 

分 类 号：R283.6[医药卫生—中药学]