基于方剂树形分析算法对《伤寒杂病论》中桂枝类方组方规律研究  

Research on the combination rules of formulas contain Cmnamomi Mmulus in the book of Treatise on Typhoid and Miscellaneous Diseases based on tree analysis algorithm

作　　者：刘欣源 邢雁辉[2] 于琦[3] 王映辉[1] 张君冬 田野[3] 王一萌 黄燕 李敬华[3] Liu Xinyuan;Xing Yanhui;Yu Qi;Wang Yinghui;Zhang Jundong;Tian Ye;Wang Yimeng;Huang Yan;Li Jinghua(Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Science,Beijing 100700,China;Information Technology Laboratory,Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Science,Beijing 100700,China;Intelligent Research and Development Center of Traditional Chinese Medicine,Institute of Information on Traditional Chinese Medicine,China Academy of Chinese Medical Science,Beijing 100700,China;Hubei University of Chinese Medicine,Wuhan 430065,China)

机构地区：[1]中国中医科学院中医药信息研究所,北京100700 [2]中国中医科学院中医药信息研究所信息技术研究室,北京100700 [3]中国中医科学院中医药信息研究所大健康智能研发中心,北京100700 [4]湖北中医药大学,武汉430065

出　　处：《国际中医中药杂志》2022年第11期1292-1297,共6页International Journal of Traditional Chinese Medicine

基　　金：中国工程科技知识中心建设项目(CKCEST-2021-1-20);中国中医科学院自主选题项目(ZZ130303)。

摘　　要：目的基于方剂树形分析算法分析《伤寒杂病论》中桂枝类方的组方规律。方法收集《伤寒杂病论》中桂枝类方,运用古今医案云平台的方剂树形分析算法对每一层的方剂进行共现计算,以获取桂枝类方的分层树形结构图。结果纳入方剂79首,药物96味,总用药频次529次,涉及7种功效。高频药物包括桂枝、炙甘草、生姜、大枣等。主要功效包括解表、温通经脉、温阳利水等。方剂树形结构图共分为7层,包含最大项为桂枝、炙甘草、生姜、大枣、芍药、麻黄、葛根,侧支药物有茯苓、白术、泽泻、干姜等。结论方剂树形分析算法可串联药物之间的相关性,展示方剂里高频共现药物间的联系,可用于经方的学习。Objective To anylyze the combination rule of prescriptions containing Cmnamomi Mmulus in the book of Treatise on Typhoid and Miscellaneous Diseases based on tree analysis algorith method.Methods By collecting prescriptions contain Cmnamomi Mmulus in the book of Treatise on Typhoid and Miscellaneous Diseases,and applying the tree analysis algorithm method on the Ancient and Modern Medical Case Cloud Platform to co-occurrence calculate each layer of the prescriptions,we got the hierarchical tree structure diagram of Cmnamomi Mmulus prescriptions.Results 79 prescriptions containing 96 medicines were included,which appeared 529 times,with 7 different functions.The medicines that are frequently appeared include Cmnamomi Mmulus,Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle,Zingiberis Rhizoma Recens,Jujubae Fructus,etc.The main effects include relieving the exterior,warming the meridians,warming yang and promoting diuresis.The tree structure diagram of the prescription is divided into seven layers,including the largest items of Cmnamomi Mmulus,Glycyrrhizae Radix Et Rhizoma Praeparata Cum Melle,Zingiberis Rhizoma Recens,Jujubae Fructus,Paeoniae Radix Alba,Ephedrae Herba,Puerariae Lobatae Radix,and the collateral drugs of Poria,Atractylodis macrocephalae rhizoma,Alismatis Rhizoma,Zingiberis Rhizoma,etc.Conclusion The formula tree analysis algorithm can connect the correlation between drugs in series,and show the relationship between a series of high-frequency co-occurrence drugs in the formula,which can be used for the learning of classics.

关 键 词：《伤寒杂病论》 方剂 树形分析算法 桂枝 组方规律 

分 类 号：R289[医药卫生—方剂学]