外周血促炎细胞因子与青年女性脑卒中后抑郁的相关性分析  

Analysis on the correlations between proinflammatory cytokines in peripheral blood and post-stroke depression in young women

作　　者：柳敏芬[1] 吴泓蔚 游芬芬 何婷[1] LIU Min-Fen;WU Hong-Wei;YOU Fen-Fen(Department of Neurology,Lishui People's Hospital,Lishui,Zhejiang 323000,China)

机构地区：[1]丽水市人民医院神经内科,浙江丽水323000 [2]丽水市人民医院血液净化科,浙江丽水323000

出　　处：《中国妇幼保健》2022年第24期4557-4560,共4页Maternal and Child Health Care of China

基　　金：浙江省卫生健康科技计划项目(2022KY1443)。

摘　　要：目的分析外周血促炎细胞因子与青年女性脑卒中后抑郁的相关性。方法选取2019年2月—2020年2月丽水市人民医院收治的80例青年女性脑卒中患者,采用蒙哥马利抑郁量表评定脑卒中后抑郁情况,采用酶联免疫吸附试验(ELISA)检测患者血清白细胞介素-6(IL-6)、γ-干扰素(IFN-γ)及肿瘤坏死因子-α(TNF-α)水平,分析其与脑卒中后抑郁发生的关系。结果80例青年女性脑卒中患者中有31例发生抑郁,发生率为38.75%,其中轻度抑郁22例,中重度抑郁9例,3组患者外周血IL-6、IFN-γ及TNF-α水平比较,差异均有统计学意义(均P<0.05)。Spearman相关性分析发现:外周血IL-6、IFN-γ及TNF-α水平与脑卒中患者抑郁发生均呈显著正相关(r=0.588,0.441,0.568,均P<0.05)。ROC曲线分析发现:外周血IL-6、IFN-γ及TNF-α联合诊断脑卒中后轻度抑郁的曲线下面积明显高于IL-6、IFN-γ单项指标的曲线下面积。ROC曲线分析发现:外周血IL-6、IFN-γ及TNF-α联合诊断脑卒中后中重度抑郁的曲线下面积明显高于IFN-γ单项指标的曲线下面积。结论外周血促炎细胞因子IL-6、IFN-γ及TNF-α水平与青年女性脑卒中后抑郁的发生呈显著正相关,对脑卒中后抑郁程度具有较高的诊断价值。Objective To analyze the correlations between proinflammatory cytokines in peripheral blood and post-stroke depression in young women.Methods A total of 80 young female stroke patients treated in Lishui People's Hospital from February 2019 to February 2020 were selected,Montgomery-Asberg Depression Rating Scale was used to evaluate post-stroke depression,enzyme linked immunosorbent assay(ELISA)was used to detect the levels of serum interleukin-6(IL-6),gamma interferon(IFN-γ),and tumor necrosis factor-α(TNF-α),the relationships with occurrence of post-stroke depression were analyzed.Results There were 31 cases of depression(38.75%)in 80 young female stroke patients,including 22 cases of mild depression and 9 cases of moderate to severe depression.There were statistically significant differences in the levels of IL-6,IFN-γ,and TNF-αin peripheral blood among the three groups(P<0.05).Spearman correlation analysis showed that the levels of IL-6,IFN-γ,and TNF-αin peripheral blood were significantly positively correlated with the occurrence of depression in stroke patients(r=0.588,0.441,0.568,all P<0.05).ROC curve analysis showed that the area under ROC curve of peripheral blood IL-6,IFN-γ,and TNF-αcombined diagnosis of mild depression after stroke was significantly higher than those of IL-6 single index and IFN-γsingle index.The area under ROC curve of peripheral blood IL-6,IFN-γ,and TNF-αcombined diagnosis of moderate and severe depression after stroke was significantly higher than that of IFN-γsingle index.Conclusion Peripheral blood pro-inflammatory cytokines IL-6,IFN-γ,and TNF-αare significantly positively correlated with the occurrence of poststroke depression in young women,which has high diagnostic value for the degree of post-stroke depression.

关 键 词：脑卒中 抑郁 促炎细胞因子 相关性 

分 类 号：R711[医药卫生—妇产科学]