妊娠期高血压疾病患者不良分娩结局的影响因素分析  

Analysis on influencing factors of adverse delivery outcomes in patients with hypertensive disorder complicating pregnancy

作　　者：肖珊珊 戴玲华[1] 孙春霞[1] 宣荣荣[1] XIAO Shan-Shan;DAI Ling-Hua;SUN Chun-Xia(Affiliated Hospital of Medical College of Ningbo University,Ningbo,Zhejiang 315020,China)

机构地区：[1]宁波大学医学院附属医院,浙江宁波315020

出　　处：《中国妇幼保健》2022年第24期4672-4675,共4页Maternal and Child Health Care of China

基　　金：浙江省医药卫生科技计划项目(2018KY710);浙江省宁波市科技项目(2019C50095)。

摘　　要：目的分析妊娠期高血压疾病患者不良分娩结局的影响因素。方法回顾性分析2019年6月—2021年4月就诊于宁波大学医学院附属医院的94例妊娠期高血压疾病患者临床资料。分析妊娠期高血压疾病患者不良分娩结局的相关影响因素。结果94例妊娠期高血压疾病患者中,发生不良分娩结局30例(31.91%),其中产后出血8例,胎盘早剥10例,羊水过少2例,产后感染3例,新生儿窒息3例,胎儿宫内窘迫4例。多因素logistic回归分析结果显示:疾病程度重度(OR=5.083,95%CI:1.176~21.980)、发病孕周<28周(OR=5.455,95%CI:1.493~19.931)、蛋白尿程度+++~++++(OR=4.333,95%CI:1.673~11.227)、分娩孕周<28周(OR=12.600,95%CI:1.401~113.312)、合并甲状腺功能减低症(OR=3.500,95%CI:1.212~10.109)、低密度脂蛋白胆固醇(LDL-C)水平异常(OR=2.514,95%CI:1.031~6.129)及高密度脂蛋白胆固醇(HDL-C)水平异常(OR=2.497,95%CI:1.028~6.064)是妊娠期高血压疾病患者不良分娩结局的高危因素(均P<0.05)。结论妊娠期高血压疾病患者不良分娩结局发生与疾病程度、蛋白尿程度、分娩孕周、合并甲状腺功能减低症、LDL-C水平及HDL-C水平有关。Objective To analyze the influencing factors of adverse delivery outcomes in patients with hypertensive disorder complicating pregnancy(HDCP).Methods The clinical data of ninety-four HDCP patients from Affiliated Hospital of Medical College of Ningbo University from June 2019 to April 2021 were retrospectively analyzed.The related factors influencing adverse delivery outcomes in HDCP patients were analyzed.Results Among ninety-four HDCP patients,30 cases(31.91%)were found with adverse delivery outcomes,including 8 cases with postpartum hemorrhage,10 cases with placental abruption,2 cases with oligohydramnion,3 cases with postpartum infection,3 cases with neonatal asphyxia,and 4 cases with fetal intrauterine distress.Multivariate logistic regression analysis showed that severe degree of the disease(OR=5.083,95%CI:1.176-21.980),gestational week of onset of the disease<28 week(OR=5.455,95%CI:1.493-19.931),degree of proteinuria(+++)-(++++)(OR=4.333,95%CI:1.673-11.227),gestational week of delivery<28 week(OR=12.600,95%CI:1.401-113.312),combining with hypothyroidism(OR=3.500,95%CI:1.212-10.109),abnormal low-density lioporotein cholesterol(LDL-C)level(OR=2.514,95%CI:1.031-6.129),and abnormal high-density lioporotein cholesterol(HDL-C)level(OR=2.497,95%CI:1.028-6.064)were high-risk factors of adverse delivery outcomes in HDCP patients(P<0.05).Conclusion The occurrence of adverse delivery outcome in HDCP patients is related to the degree of disease,the degree of proteinuria,gestational week of delivery,combining with hypothyroidism,LDL-C level,and HDL-C level.

关 键 词：妊娠期高血压疾病 分娩结局 影响因素 

分 类 号：R714.24[医药卫生—妇产科学]