Jigsaw puzzle of SARS-CoV-2 RBD evolution and immune escape  

作　　者：Chunyan Yi Xiaoyu Sun Zhiyang Ling Bing Sun 

机构地区：[1]State Key Laboratory of Cell Biology,Shanghai Institute of Biochemistry and Cell Biology,Center for Excellence in Molecular Cell Science,Chinese Academy of Sciences,University of Chinese Academy of Sciences,Shanghai 200031,China [2]School of Life Science and Technology,ShanghaiTech University,100 Haike Road,Shanghai 201210,China

出　　处：《Cellular & Molecular Immunology》2022年第7期848-851,共4页中国免疫学杂志（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(32100123 and 32100751);the Ministry of Science and Technology of China(2018YFA0507402).

摘　　要：The outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which causes coronavirus disease 2019(COVID-19),has posed a tremendous threat to global health,resulting in over 510 million infections and at least 6.23 million deaths worldwide as of early May 2022.Extensive efforts to fight against the SARS-CoV-2 pandemic have accelerated the research and clinical development of various vaccines and neutralizing antibodies(NAbs)[1,2].However,SARS-CoV-2 has an exceptional ability to mutate and evade the human immune system,which highlights the surveillance of SARS-CoV-2 evolution to anticipate and facilitate a timely response to new variants that could impact viral transmissibility and the efficacy of vaccines and antibody therapies[3].

关 键 词：ACUTE RESPIRATORY EVOLUTION 

分 类 号：R563.1[医药卫生—呼吸系统]