武汉雷神山医院60例新型冠状病毒肺炎患者中西医结合诊疗情况及效果评价  

Effectiveness evaluation of integrative medicine in treatment of 60 patients with coronavirus disease 2019 pneumonia in Wuhan Leishenshan Hospital

作　　者：芦志丹[1] 冯卓[1] 李丛新 刘晨曦 尚东[2] 李楠[1] Lu Zhidan;Feng Zhuo;Li Congxin;Liu Chenxi;Shang Dong;Li Nan(Department of Emergency,the First Affiliated Hospital of Dalian Medical University,Dalian 116000,Liaoning,China;Department of General Surgery of Integrated Traditional Chinese and Western Medicine Therapy,the First Affiliated Hospital of Dalian Medical University,Dalian 116000,Liaoning,China)

机构地区：[1]大连医科大学附属第一医院急诊科,辽宁大连116000 [2]大连医科大学附属第一医院中西医结合普外科,辽宁大连116000

出　　处：《中国中西医结合急救杂志》2022年第5期545-549,共5页Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care

摘　　要：目的探讨中医中药在新型冠状病毒肺炎(新冠肺炎)治疗中发挥的作用。方法采用回顾性研究方法。收集作者作为援鄂医疗队队员,于2020年2月14日至3月29日在武汉雷神山医院参与救治的60例新冠肺炎患者的临床资料,包括一般资料、实验室数据、治疗方案、住院情况等多个维度信息。根据治疗方法不同将患者分为中草药治疗组和常规治疗组,每组30例;再根据入院时病情严重程度将患者分为非重症(轻型和普通型)和重症(重型及危重型)。中草药治疗组包括非重症15例和重症15例;常规治疗组包括非重症16例和重症14例。所有患者均采用了西药常规治疗,包括口服阿比朵尔、磷酸氯喹、奥司他韦、洛匹那韦利托那韦(克力芝),以及α2b干扰素雾化、静脉注射利巴韦林。依据患者病情,在西药治疗基础上联合中成药和(或)中药汤剂。比较是否采用中药治疗两组及不同病情程度患者上述指标的差异;采用肯德尔相关性分析法分析抗病毒药物使用种类、抗病毒药物使用时间与患者总病程的相关性;采用二元Logistic回归分析归纳总病程与抗病毒药物使用种类、抗病毒药物使用时间之间的回归方程,并进行热图分析。结果60例患者中男性25例,女性35例;年龄28~95岁,平均(61.73±14.31)岁;33例患者既往存在基础疾病。患者中医中药的参与率达到了96.67%(58/60)。与非重症患者比较,重症患者的年龄更大(岁:67.55±11.32比56.29±2.66),既往存在基础疾病的比例显著升高〔79.3%(23/29)比32.3%(10/31)〕,发病时间更短(d:12.21±9.22比23.52±16.40),住院时间更长(d:26.75±8.18比17.90±8.68),使用的抗病毒药物种类更多(种:3.10±1.34比2.03±1.11),且使用时间更长(d:24.79±12.86比14.48±10.14),使用抗菌药物的患者比例更高〔55.2%(16/29)比25.8%(8/31)〕,差异均有统计学意义(均P<0.05)。而中草药治疗组病程较常规治疗组明显缩短(d:36.57±9.8Objective To explore the role of Chinese medicine in the treatment of coronavirus disease 2019(COVID-19).Methods As a retrospective study was conducted,data including general information,laboratory data,treatment plan,hospital-stay information from patients with COVID-19 whom were treated in Wuhan Leishenshan Hospital where the author was working from February 14 to March 29,2020 was collected.The patients were divided into Chinese herbal medicine group(CHMG,n=30)and conventional treatment group(CTG,n=30)according to different treatment methods,and stratified according to disease severity as non-severe(mild and moderate)patients and severe(severe and critical)patients.There were 15 non-severe cases and 15 severe cases in the CHMG,while 16 non-severe cases and 14 severe cases in the CTG.Western medicine was applied to all patients,including oral abidol,chloroquine phosphate,oseltamivir,creidech,aerosol ofαinterferon 2b,and intravenous ribavirin.According to the patient's condition,western medicine treatment was combined with Chinese patent medicine and/or Chinese herbal medicine.Analysis on the differences of the indicators above between the two groups and their subgroups were conducted.Kendall's correlation analysis was used to analyze the correlation between the types of antiviral medication use,the length of antiviral medication use and the total course of disease.The binary Logistic regression analysis was used to obtain the regression equation between the total course of disease and the types of antiviral medication use,the length of antiviral medication use,and heat map analysis was carried out.Results Among the 60 patients,there were 25 male and 35 female patients,aging from 28-95 years old with an average age of(61.73±14.31)years old,33 cases had chronic diseases before admission,and 96.67%(58/60)patients received Chinese patent medicine and/or Chinese herbal medicine.Compared with non-severe patients,severe patients had older age(year-old:67.55±11.32 vs.56.29±2.66),a higher proportion of patients with

关 键 词：新型冠状病毒肺炎 中草药 中西医结合 

分 类 号：R563.1[医药卫生—呼吸系统]