2,3-二氯-5-三氟甲基吡啶的应用、合成及其市场分析  

Application,Synthesis and Market Analysis of 2,3-Dichloro-5-(trifluoromethyl)pyridine

作　　者：于万金[1] 杨文龙 魏攀 张景乾 马亚锋 林胜达[1] 刘敏洋 肖新宝 刘创 陈先进 YU Wan-jin;YANG Wen-long;WEI Pan;ZHANG Jing-qian;MA Ya-feng;LIN Sheng-da;LIU Min-yang;XIAO Xin-bao;LIU Chuang;CHEN Xian-jin(State Key Laboratory of Fluorinated Greenhouse Gases Replacement and Control Treatment,Zhejiang Research Institute of Chemical Industry Co.,Ltd.,Hangzhou,Zhejiang 310023,China;Shaanxi Zhonglan Chemical Technology New Materials Co.,Ltd.,Weinan,Shaanxi 715500,China;Lanqi Biotech(Zhejiang)New Materials Co.,Ltd.,Hangzhou,Zhejiang 310020,China;Hubei Zhonglan Hongyuan New Energy Materials Co.,Ltd.,Huanggang,Hubei 438600,China)

机构地区：[1]浙江省化工研究院有限公司含氟温室气体替代及控制处理国家重点实验室,浙江杭州310023 [2]陕西中蓝化工科技新材料有限公司,陕西渭南715500 [3]蓝启生科(浙江)新材料有限公司,浙江杭州310020 [4]湖北中蓝宏源新能源材料有限公司,湖北黄冈438600

出　　处：《浙江化工》2022年第12期1-6,16,共7页Zhejiang Chemical Industry

摘　　要：综述了2,3-二氯-5-三氟甲基吡啶的主要用途与合成方法。2,3-二氯-5-三氟甲基吡啶是非常有应用价值的含氟中间体,广泛应用于农药、医药、兽药、精细化工等领域。以关键中间体2,3-二氯-5-三氟甲基吡啶为原料,可生产除草剂高效氟吡甲禾灵,杀虫剂氟啶脲、吡虫隆,杀菌剂氟啶胺、氟啶酰菌胺、氟吡菌酰胺等6个大宗下游农药产品。以2-氯-5-三氟甲基吡啶为原料制备2,3-二氯-5-三氟甲基吡啶的工艺路线简单、安全环保,但其原料成本较高。简要介绍了产品的市场情况,以供同仁参考。The main uses and synthesis methods of 2,3-dichloro-5-(trifluoromethyl)pyridine were reviewed.2,3-Dichloro-5-(trifluoromethyl)pyridine is a fluorine-containing intermediate with great application value,which is widely used in pesticides,medicine,veterinary drugs,fine chemicals and other fields.With the key intermediate 2,3-dichloro-5-(trifluoromethyl)pyridine as raw material,it can produce six bulk downstream pesticide products such as herbicide high efficiency flumethazolin,insecticide flufenamide,imidaclopron,fungicide fluidinamide,fluylamide,fluylidamide.The process route of preparing 2,3-dichloro-5-(trichloromethyl)pyridine from 2-chloro-5-(trifluoromethyl)pyridine is simple,safe and environmentally friendly,but its raw material cost is high.The market situation of the product is briefly introduced for the reference of colleagues.

关 键 词：2 3-二氯-5-三氟甲基吡啶 2-氯-5-三氟甲基吡啶 3-甲基吡啶 含氟农药中间体 氯化 氟化 

分 类 号：TQ450.1[化学工程—农药化工]