对甲氧基苯甲醛绿色合成工艺研究  

Research on Green Synthesis Process of p-methoxybenzaldehyde

作　　者：石兴争 张永富 茹雨晴 Shi Xingzheng;Zhang Yongfu;Ru Yuqing(Shandong Lusheng Pharmaceutical Co.,Ltd.,Production Department,Dezhou 253070,China;Qingdao Common Development Consulting Co.,Ltd.,Qingdao 266199,China;College of Chemical Engineering,Qingdao University of Science and Technology,Qingdao 266042,China)

机构地区：[1]山东鲁盛制药有限公司生产部,山东德州253070 [2]青岛和合共生顾问有限公司,山东青岛266199 [3]青岛科技大学化工学院,山东青岛266042

出　　处：《山东化工》2022年第23期22-24,共3页Shandong Chemical Industry

摘　　要：通过对比对甲氧基苯甲醛(PMBA)各种合成工艺路线的优缺点,最终选择对羟基苯甲醛(PHBA)的碳酸二甲酯(DMC)甲基化法工艺进行研究,通过工艺优化研究确定最佳工艺条件为:以ZSM-5型分子筛为催化剂,n(PHBA)∶n(DMC)=1∶4,m(PHBA)∶m(ZSM-5)=1∶0.1,反应温度为145℃,反应时间为5 h,此条件下PHBA转化率高达99.0%以上,PMBA的选择性大于96%,催化剂ZSM-5可循环套用,反应无废水和废固产生,实现绿色合成目标。By comparing the advantages and disadvantages of various synthetic process routes of p-methoxybenzaldehyde(PMBA),the dimethyl carbonate(DMC)methylation process of p-hydroxybenzaldehyde(PHBA)was finally selected for research,and determined through process optimization research,the best process conditions are:ZSM-5 molecular sieve as catalyst,n(PHBA)∶n(DMC)=1∶4,m(PHBA)∶m(ZSM-5)=1∶0.1,reaction temperature is 145℃,the reaction time is 5 h,the conversion rate of PHBA is as high as 99.0%or more,and the selectivity of PMBA is more than 96%.

关 键 词：对羟基苯甲醛 甲氧基苯甲醛 碳酸二甲酯 甲基化反应 

分 类 号：TQ244.1[化学工程—有机化工]