药物共结晶过程的影响因素研究进展  

Research Progress on Factors Influencing Drug Co-crystallization Process

作　　者：肖鹏 李尊华 罗杰 欧光川 肖新生 丁满花 Xiao Peng;Li Zunhua;Luo Jie;Ou Guangchuan;Xiao Xinsheng;Ding Manhua(College of Chemistry and Bioengineering,Hunan University of Science and Engineering,Yongzhou 425199,China)

机构地区：[1]湖南科技学院化学与生物工程学院,湖南永州425199

出　　处：《山东化工》2022年第23期92-95,共4页Shandong Chemical Industry

基　　金：2020年湖南省教育厅科学研究项目优秀青年课题(湘教通【2020】264号,20B253);2020年湖南科技学院科学研究课题(湘科院校发【2020】52号,20XKY067);汕尾市2020年广东省科技专项资金(“大专项+任务清单”)项目。

摘　　要：介绍了共结晶过程的三个影响因素的国内外研究进展,包括共结晶热力学、共结晶动力学和共结晶流体力学。其中,共结晶热力学主要介绍了溶度积、溶剂类型、过饱和度、相溶度图和三元相图对共结晶的影响;共结晶动力学主要介绍了成核和生长对共结晶的影响;共结晶流体力学介绍了搅拌转速与液流形式对共结晶的影响。希望能为从事药物共晶研究的科研工作者和工程技术人员产生有益的帮助。The domestic and foreign research progress of three influencing factors of co-crystallization process,including co-crystallization thermodynamics,co-crystallization kinetics and co-crystallization hydrodynamics,is introduced.Among them,co-crystallization thermodynamics mainly introduces the effects of solubility product,solvent type,supersaturation,phase solubility diagram and ternary phase diagram on co-crystallization;co-crystallization kinetics mainly introduces the effects of nucleation and growth on co-crystallization;co-crystallization hydrodynamics introduces the influence of stirring speed and flow pattern on co-crystallization.It is hoped that this will be of useful help to researchers and engineering technicians engaged in the study of drug co-crystals.

关 键 词：共结晶 相溶度图 三元相图 结晶热力学 结晶动力学 结晶流体力学 

分 类 号：TQ460.2[化学工程—制药化工]