不同剂量木犀草素在大鼠体内药动学的比较  

Comparison of in vivo pharmacokinetics of different doses of luteolin in rats

作　　者：涂亮星 杨如月 刘佳丽 程勐 金一[1] 奉建芳 TU Liang-xing;YANG Ru-yue;LIU Jia-li;CHENG Meng;JIN Yi;FENG Jian-fang(National Engineering Research Center for Manufacturing Technology of Solid Chinese Herbal Preparations,Jiangxi University of Chinese Medicine,Nanchang 330006,China;The Hospital Affiliated to Jiangxi University of Chinese Medicine,Nanchang 330006,China;College of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China)

机构地区：[1]江西中医药大学中药固体制剂制造技术国家工程研究中心,江西南昌330006 [2]江西中医药大学附属医院,江西南昌330006 [3]广西中医药大学药学院,广西南宁530200

出　　处：《中成药》2022年第12期3753-3757,共5页Chinese Traditional Patent Medicine

基　　金：江西中医药大学“1050”青年人才工程项目(5142001012);江西中医药大学博士启动项目(2018BSZR018)。

摘　　要：目的比较不同剂量木犀草素在大鼠体内的药动学。方法大鼠随机分为6组,分别灌胃给予10、20、40、80、120 mg/kg木犀草素及尾静脉注射给予木犀草素注射液(4 mg/kg),于不同时间点采血,HPLC法测定木犀草素血药浓度,计算主要药动学参数。结果在10~80 mg/kg剂量范围内,AUC_(0~∞)、C_(max)与剂量的相关系数分别为0.9966、0.9694。当剂量为120 mg/kg时,C_(max)不再增加,AUC_(0~∞)与剂量的相关系数为0.9799。t_(1/2)与剂量无相关性。结论在10~80 mg/kg剂量范围内木犀草素呈现线性动力学特征,剂量增加至120 mg/kg后不明显。AIM To compare the in vivo pharmacokinetics of different doses of luteolin in rats.METHODS Rats were randomly assigned into six groups and given intragastric administration of 10,20,40,80,120 mg/kg luteolin and tail intravenous injection administration of Luteolin injection(4 mg/kg),respectively,after which blood collection was made at different time points,HPLC was adopted in the plasma concentration determination of luteolin,and main pharmacokinetic parameters were calculated.RESULTS At the dose range of 10-80 mg/kg,the correlation coefficients between AUC_(0-∞)and dose,and C_(max)and dose were 0.9966 and 0.9694,respectively.When the dose was 120 mg/kg,C_(max)was no longer increased,and the correlation coefficient between AUC 0_(~∞)and dose was 0.9799.No correlation between t_(1/2)and dose was found.CONCLUSION Luteolin demonstrates linear dynamic characteristics at the dose range of 10-80 mg/kg,which is not obvious after the dose is increased to 120 mg/kg.

关 键 词：木犀草素 剂量 体内药动学 HPLC 

分 类 号：R969.1[医药卫生—药理学]