紫丁香叶化学成分研究  

Chemical constituents from the leaves of Syringa oblata

作　　者：祝文博[1] 孙延平[1] 王知斌[1] 杨炳友[1] 王秋红 匡海学[1] ZHU Wen-bo;SUN Yan-ping;WANG Zhi-bin;YANG Bing-you;WANG Qiu-hong;KUANG Hai-xue(Ministry of Education Key Laboratory for Basic and Application Research of Beiyao,Heilongjiang University of Chinese Medicine,Harbin 150040,China;School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China)

机构地区：[1]黑龙江中医药大学,教育部北药基础与应用研究重点实验室,黑龙江哈尔滨150040 [2]广东药科大学中药学院,广东广州510006

出　　处：《中成药》2022年第12期3872-3878,共7页Chinese Traditional Patent Medicine

基　　金：国家中医药管理局-国家中医药领军人才支持计划“岐黄学者”项目(2018);中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者(2021);黑龙江省“头雁”团队支持项目(黑龙江省头雁行动领导小组文件[2019]5号)。

摘　　要：目的研究紫丁香叶Syringa oblata L.的化学成分。方法对紫丁香叶75%乙醇提取物利用硅胶柱色谱、ODS反相柱色谱和制备型高效液相色谱等进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到20个化合物,分别鉴定为syringalactone B(1)、10-hydroxyligstroside(2)、sclerochitonoside A(3)、methyloleoside 7-ethyl ester(4)、2,2-dimethyl-2 H-1-benzopyran-6-ol(5)、tetracentronside B(6)、环橄榄树脂素(7)、meso-2,3-di(3′,4′-methylenedioxybenzyl)butane-1,4-diol(8)、羟基酪醇乙酰酯(9)、2-(4-hydroxyphenethyl)acetate(10)、4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate(11)、bungein A(12)、staphylionoside D(13)、icariside C3(14)、7-hydroxy-1-isochromanone(15)、megastigmane(16)、铁冬青酸(17)、2α,3α,23-三羟基-12-烯-28-乌苏酸(18)、坡模酸(19)、木姜子醇(20)。结论化合物5~6、8、10~11、13~15、18、20首次从木犀科植物中分离得到,化合物9、12首次从丁香属植物中分离得到。AIM To study the chemical constituents from leaves of Syringa oblata L..METHODS The 75%ethanol extract from S.oblata was isolated and purified by silica gel,ODS and preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Twenty compounds were isolated and identified as syringalactone B(1),10-hydroxyligstroside(2),sclerochitonoside A(3),methyloleoside 7-ethyl ester(4),2,2-dimethyl-2 H-1-benzopyran-6-ol(5),tetracentronside B(6),cycloolivil(7),meso-2,3-di(3′,4′-methylenedioxybenzyl)butane-1,4-diol(8),hydroxytyrosol acetate(9),2-(4-hydroxyphenethyl)acetate(10),4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate(11),bungein A(12),staphylionoside D(13),icariside C3(14),7-hydroxy-1-isochromanone(15),megastigmane(16),rotundic acid(17),2α,3α,23-trihydroxyurs-12-en-28-oic acid(18),pomolic acid(19)and listeanol(20).CONCLUSION Compounds 5-6,8,10-11,13-15,18,20 are isolated from the Oleaceae for the first time,compounds 9,12 are isolated from the genus Syringa for the first time.

关 键 词：紫丁香 叶 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]