牛结节性皮肤病疫苗研究进展  

Research Progress on Vaccines of Lumpy Skin Disease

作　　者：李林[1] 巩明霞[1] 迟田英[1] 王英丽[1] 于小静[1] 杜秋明 南文龙[1] 陈义平[1] 王志亮[1] Li Lin;Gong Mingxia;Chi Tianying;Wang Yingli;Yu Xiaojing;Du Qiuming;Nan Wenlong;Chen Yiping;Wang Zhiliang(China Animal Health and Epidemiology Center,Qingdao,Shandong 266032,China;Yanbian Center for Animal Disease Prevention and Control,Yanji,Jilin 133400,China)

机构地区：[1]中国动物卫生与流行病学中心,山东青岛266032 [2]延边州动物疫病预防控制中心,吉林延吉133400

出　　处：《中国动物检疫》2023年第1期102-108,共7页China Animal Health Inspection

摘　　要：牛结节性皮肤病(LSD)是2019年8月传入我国的新发传染病,对养牛业产生了重大经济影响。疫苗免疫是控制LSD传播的关键措施。目前只有商品化弱毒活疫苗(LAV)用于预防LSD,包括同源弱毒活疫苗和异源羊痘弱毒活疫苗,而灭活疫苗以及多种病毒的重组亚单位疫苗正在研究中;不管是同源疫苗还是异源疫苗,大都具有良好的临床保护效果,但部分疫苗不能提供足够的免疫保护;进行良好的疫苗质量控制可有效避免疫苗生产过程中的外源病毒污染以及类疫苗重组毒株的产生。我国可进一步借鉴国际先进经验,积极开展疫苗研发,以及流行病学、监测诊断等相关防控技术研究,尽早消灭LSD。本文着重介绍了国内外常用疫苗的种类、副作用及其免疫效果和质量控制等,可为该病控制和消灭提供技术支持。Lumpy skin disease(LSD)was an emerging infectious disease introduced into China in August 2019,bringing a significant economic impact on the cattle industry.Vaccination was a key measure to control LSD spreading,but only commercial live attenuated vaccines(LAV)including homologous live attenuated vaccines and heterologous live attenuated capripox vaccines could be used to prevent LSD,while inactivated vaccines and recombinant subunit vaccines for multiple viruses were under research;whether homologous vaccines or heterologous ones had good clinical protective effects,but some of them failed to produce sufficient immunity;and the contamination of exogenous viruses and the production of vaccine-like recombinant strains during the process of vaccine production could be avoided by good vaccine quality control.In China,for the purpose of eliminating LSD soonest,relevant researches on prevention and control technologies including vaccines,epidemiology,monitoring and diagnosis should be conducted with reference to international advanced experience.In the paper,the types,side effects,immune effects and quality control of vaccines commonly used both at home and abroad were introduced,which technically supported the control and eradication of the disease.

关 键 词：牛结节性皮肤病 疫苗 山羊痘病毒 绵羊痘病毒 

分 类 号：S851.3[农业科学—预防兽医学]