大疱性类天疱疮与2型炎症相关性的研究进展  

Correlation between bullous pemphigoid and type 2 inflammation

作　　者：周瑶 李帼敏 许志军 徐洁 郑金津 房浩 薛汝增 ZHOU Yao;LI Guomin;XU Zhijun;XU Jie;ZHENG Jinjin;FANG Hao;XUE Ruzeng(Dermatology Hospital,Southern Medical University,Guangzhou 510091,China)

机构地区：[1]南方医科大学皮肤病医院,广东广州510091

出　　处：《皮肤性病诊疗学杂志》2022年第6期579-582,共4页Journal of Diagnosis and Therapy on Dermato-venereology

摘　　要：大疱性类天疱疮(BP)是一种好发于老年人的自身免疫性水疱病。大部分大疱性类天疱疮患者有明显瘙痒症状,伴有血清总IgE、外周血嗜酸性粒细胞以及IL-4、IL-13等2型细胞因子水平升高。多种Th2相关炎症细胞及介质参与BP发病机制,其中Th2细胞及2型细胞因子是2型炎症反应的核心驱动因素,表明BP患者存在2型炎症反应。同时奥马珠单抗、度普利尤单抗成功治疗大疱性类天疱疮的案例进一步提示大疱性类天疱疮与2型炎症存在密切相关性。本文就大疱性类天疱疮与2型炎症的相关性作一综述。Bullous pemphigoid(BP)is one of the common autoimmune blister diseases that mainly affects the elderly.Most bullous pemphigoid patients have obvious symptom of pruritus,accompanied by elevated levels of serum total IgE,peripheral blood eosinophils,and type 2 cytokines such as IL-4 and IL-13.It was found that a variety of Th2-related inflammatory cells and mediators are involved in the pathogenesis of BP,while Th2 cells and type 2 cytokines are the core drivers of type 2 inflammatory response which indicates that type 2 inflammatory response exists in BP patients.At the same time,the successful treatment of bullous pemphigoid with omalizumab and dupilumab further suggests that bullous pemphigoid is closely related to type 2 inflammation.

关 键 词：大疱性类天疱疮 2型炎症 TH2细胞 嗜酸性粒细胞 IGE IL-4 IL-13 瘙痒 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]