变应原鼻腔激发试验中国专家共识(2022,北京)  

China expert consensus on allergen nasal provocation test(2022,Beijing)

作　　者：王洪田 于睿莉 安云芳[2] 刘锋[3] 王天生[4] 杨钦泰[5] 陆美萍[6] 邱前辉[7] 王向东[8] 陈建军[9] 孟粹达[10] 谢志海[11] 孙悦奇[12] 孟娟[3] 曾明[13] 许成利 王英[15] 杨玉成[16] 张维天 唐隽[18] 杨艳莉 徐睿[20] 喻国冻 石照辉 魏欣[23] 叶惠平 孙亚男[25] 余少卿[26] 张天虹[27] 雍军[28] 杭伟[29] 许元腾[30] 许昱[31] 谭国林[4] 孙娜 洪海裕[33] 杨贵 李幼瑾[35] 叶菁[36] 左可军[20] 张立强[37] 王学艳 李华斌 中国鼻病研究协作组 WANG Hongtian;YU Ruili;AN Yunfang;LIU Feng;WANG Tiansheng;YANG Qintai;LU Meiping;QIU Qianhui;WANG Xiangdong;CHEN Jianjun;MENG Cuida;XIE Zhihai;SUN Yueqi;MENG Juan;ZENG Ming;XU Chengli;WANG Ying;YANG Yucheng;ZHANG Weitian;TANG Jun;YANG Yanli;XU Rui;YU Guodong;SHI Zhaohui;WEI Xin;YE Huiping;SUN Yanan;YU Shaoqing;ZHANG Tianhong;YONG Jun;HANG Wei;XU Yuanteng;XU Yu;TAN Guolin;SUN Na;HONG Haiyu;YANG Gui;LI Youjin;YE Jing;ZUO Kejun;ZHANG Liqiang;WANG Xueyan;LI Huabin;Chinese Rhinopathy Research Cooperation Group(Department Allergy and Center of Allergy,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China;Department of Otolaryngology,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Otolaryngology Head and Neck Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Otolaryngology Head and Neck Surgery,Third Xiangya Hospital,Central South University,Changsha 410013,China;Department of Otolaryngology Head and Neck Surgery&Department of Allergy,the Third Affiliated Hospital of Sun Yat-sen University,Guangzhou 510630,China;Department of Otolaryngology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Otolaryngology Head and Neck Surgery,Guangdong Provincial People’s Hospital,Guangzhou 510080,China;Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China;Department of Otolaryngology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Department of Otolaryngology Head and Neck Surgery,China-Japan Union Hospital of Jilin University,Changchun 130033,China;Department of Otolaryngology Head and Neck Surgery,Xiangya Hospital,Central South University,Changsha 410008,China;Department of Otolaryngology,the Seventh Affiliated Hospital of Sun Yat-sen University,Shenzhen 518170,China;Department of Otolaryngology,Head and Neck Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of

机构地区：[1]首都医科大学附属北京世纪坛医院变态反应科和变态反应中心,北京100038 [2]山西医科大学第二医院耳鼻喉科,太原030001 [3]四川大学华西医院耳鼻咽喉头颈外科,成都610041 [4]中南大学湘雅三医院耳鼻咽喉头颈外科,长沙410013 [5]中山大学附属第三医院耳鼻咽喉头颈外科和变态反应(过敏)科,广州510630 [6]南京医科大学第一附属医院耳鼻喉科,南京210029 [7]广东省人民医院耳鼻咽喉头颈外科,广州510080 [8]首都医科大学附属北京同仁医院耳鼻咽喉头颈外科,北京100730 [9]华中科技大学同济医学院附属协和医院耳鼻喉科,武汉430022 [10]吉林大学中日联谊医院耳鼻咽喉头颈外科,长春130033 [11]中南大学湘雅医院耳鼻咽喉头颈外科,长沙410008 [12]中山大学附属第七医院耳鼻咽喉科,深圳518107 [13]华中科技大学同济医学院附属同济医院耳鼻咽喉头颈外科,武汉430030 [14]广西医科大学第二附属医院耳鼻咽喉头颈外科,南宁530007 [15]郑州大学第一附属医院鼻科,郑州450052 [16]重庆医科大学附属第一医院耳鼻咽喉头颈外科,重庆400016 [17]上海交通大学医学院附属第六人民医院耳鼻咽喉头颈外科,上海200233 [18]佛山市第一人民医院耳鼻咽喉头颈外科,佛山528000 [19]昆明医科大学第一附属医院耳鼻喉一科,昆明650032 [20]中山大学附属第一医院耳鼻咽喉科医院耳鼻喉科,广州510080 [21]贵州医科大学附属医院耳鼻咽喉科,贵阳550001 [22]深圳市龙岗区耳鼻咽喉医院(深圳市耳鼻咽喉研究所)鼻及颅底外科,深圳518116 [23]海南省人民医院/海南医学院附属海南医院耳鼻咽喉头颈外科,海口570311 [24]贵州省人民医院耳鼻咽喉科,贵阳550002 [25]哈尔滨医科大学附属第二医院耳鼻咽喉头颈外科,哈尔滨150001 [26]同济大学附属同济医院耳鼻咽喉头颈外科,上海200065 [27]哈尔滨医科大学附属第一医院耳鼻咽喉头颈外科,哈尔滨1500

出　　处：《中国眼耳鼻喉科杂志》2023年第1期1-10,共10页Chinese Journal of Ophthalmology and Otorhinolaryngology

基　　金：国家自然科学基金杰出青年基金(81725004);国家自然科学基金项目(81670901、81371074、81870706、81873689、81670906、81974140、82160210);国家重点研发计划(2022YFC2504100);北京市教委-北京市自然科学基金联合资助重点项目(KZ202110025030);上海市科委优秀学科带头人项目(19XD4010000);上海市耳鼻咽喉疾病临床中心重大专项(20MC920200);广东省中医药局科研项目(20191063);深圳市科技计划项目JCYJ(20210324121413037)。

摘　　要：鼻腔激发试验(NPT)是诱发鼻腔出现类似变应性鼻炎(AR)症状或症状加重的临床试验。用变应原进行的NPT是诊断AR的重要方法,但目前国内外尚没有统一的变应原使用标准、操作标准和结果判定标准。中国鼻病研究协作组(CRRCG)召集国内中青年鼻科和变态反应科专家,基于临床经验和循证医学证据制订了变应原NPT专家共识。本共识聚焦变应原NPT的适应证、禁忌证、变应原试剂标准、操作标准、阳性判定标准、检查前后注意事项等,为NPT的临床应用提供指导。Nasal provocation test(NPT) with allergen is known as an important standard for the diagnosis of allergic rhinitis(AR). However, there is no unified allergen use standard, operation protocol and result judgement standard in the world. The China Rhinopathy Research Cooperation Group(CRRCG) convened young and middle-aged nasal experts in China to formulate an expert consensus on NPT with allergen based on clinical experience and medical evidences. This consensus focuses on the indications, contraindications, allergen reagent standards, operation standards, positive determination standards, precautions before and after test of NPT with allergen, and provides guidance for clinical application.

关 键 词：鼻腔激发试验 变应原 变应性鼻炎 专家共识 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]