铁化合物功能化复合纤维的制备及其缓释CO性能  

Preparation of electrospun composite fibers functionalized with an iron complex and their CO-release behavior

作　　者：张祖儿 林巧巧 肖志音[1] 翟云云[1] 姜秀娟[1] 刘小明[1] ZHANG Zuer;LIN Qiaoqiao;XIAO Zhiyin;ZHAI Yunyun;JIANG Xiujuan;LIU Xiaoming(College of Biological,Chemical Science and Engineering,Jiaxing University,Jiaxing 314001,China)

机构地区：[1]嘉兴学院生物与化学工程学院,嘉兴314001

出　　处：《复合材料学报》2022年第12期5846-5855,共10页Acta Materiae Compositae Sinica

基　　金：国家自然科学基金(21807047);浙江省自然科学基金(LY19B010001);国家级“大学生创新创业训练计划”项目(202110354035)。

摘　　要：CO缓释材料对CO药用价值研究具有重要意义。本文以二甲基乙酰胺、丙酮为溶剂,铁化合物[Fe(η^(5)-Cp)(CO)_(2) I]为铁基一氧化碳释放剂(FeCORM),醋酸纤维素(CA)、聚乙烯吡咯烷酮(PVP)为基体聚合物,通过静电纺丝技术制备了不同FeCORM含量的微纳米复合纤维材料,并通过ATR-FTIR、UV-vis DRS、SEM等技术对有关材料进行了表征。研究了这些材料在不同光源(蓝、绿、红)照射下CO释放行为,分析了其CO释放动力学,并定量分析了不同材料释放CO的量。结果表明:复合纤维材料释放CO的速率与FeCORM含量及光源波长有关,一般含量越低、波长越短则释放速率越快;其释放过程符合一级动力学模型,表观速率常数(k_(obs))在1.59~0.11 min^(−1)之间、半衰期t_(1/2)在0.4~6.3 min左右。复合纤维材料释放CO的剂量y与FeCORM的质量百分含量x间呈良好线性依赖关系,满足方程式y=0.0284x−0.0158。CO-releasing materials are valuable for CO medicinal applications.Herein,by using an iron complex,[Fe(η^(5)-Cp)(CO)_(2) I]as iron-based carbon monoxide-releasing molecule(FeCORM),cellulose acetate(CA)and polyvinylpyrrolidone(PVP)as matrix polymers,CA-PVP-based composite fibers with various amounts of FeCORM were prepared via electrospinning technology in a mixture solution of dimethylacetamide/acetone.The composite fibers were characterized by means of ATR-FTIR,UV-vis DRS,SEM techniques.CO-releasing performance of the composite fibers was then investigated upon irradiation of blue/green/red lights,and their corresponding kinetic data were obtained,respectively.The amounts of CO released by the composite fibers were further quantified.Our results demonstrate that the rates of CO-release for the composite fibers are depending on both the contents of FeCORM and the wavelengths of the light sources.Generally,the lower the content and the shorter the wavelength,the faster the release rate should be.Additionally,first-order kinetics are assigned to the CO-release process of the composite fibers,with a rate constant k_(obs) between 1.59-0.11 min^(−1),and a half-life t_(1/2) between 0.4-6.3 min,respectively.Furthermore,a satisfied linear-relationship is estimated between the dose of released CO for the composite fibers y and the mass percentage of FeCORM x with the equation following:y=0.0284x−0.0158.

关 键 词：一氧化碳 铁羰基 静电纺丝 醋酸纤维素 聚乙烯吡咯烷酮 复合纤维 光诱导 

分 类 号：TQ460.4[化学工程—制药化工] TQ340.47[理学—化学] O69