基于3D打印载银聚乙烯醇-羧甲基壳聚糖-海藻酸钠水凝胶伤口敷料构建及性能表征  

Construction and characterization of silver-loaded polyvinyl alcohol-carboxymethyl chitosan-sodium alginate hydrogel wound dressing based on 3D printing

作　　者：陈凯[1] 柴琦 王丰艳 冯存傲 张德坤[1] CHEN Kai;CHAI Qi;WANG Fengyan;FENG Cun'ao;ZHANG Dekun(School of Materials and Physics,China University of Mining and Technology,Xuzhou 221116,China)

机构地区：[1]中国矿业大学材料与物理学院,徐州221116

出　　处：《复合材料学报》2022年第12期5879-5891,共13页Acta Materiae Compositae Sinica

基　　金：国家自然科学基金(51875564);江苏省自然科学基金(BK20211243)。

摘　　要：为设计一种对伤口无损伤、抗菌效果好、促进伤口愈合的新型伤口敷料,选择聚乙烯醇(PVA)、羧甲基壳聚糖(CMCS)和海藻酸钠(SA)作为原料,将纳米银复合到PVA-CMCS-SA水凝胶中,基于3D打印构建载银PVA-CMCS-SA水凝胶伤口敷料,对水凝胶伤口敷料的微观形貌、力学性能、吸水保湿率、生物相容性、抗菌性能、体外凝血性能等进行研究。结果表明:3D打印制备的水凝胶伤口敷料具有良好的尺寸结构稳定性,力学性能良好,最大抗拉强度可达到1000 kPa左右,循环拉伸和循环压缩性能均表现良好;由于3D打印出的网格结构,3D打印水凝胶伤口敷料的吸水性、保湿性、体外凝血性能、透气性及抗菌性能均表现良好;对大肠杆菌和金黄色葡萄球菌的抑菌率最高分别可达到64%和54%;具有低的细胞毒性和良好的生物相容性;3D打印的方法能够将水凝胶与创可贴结合,保证了伤口敷料的实用性。研究表明3D打印载银水凝胶PVA-CMCS-SA可作为一种良好的伤口敷料材料。In order to design a new type of wound dressing that does not damage the wound,has good antibacterial effect,and promotes wound healing,polyvinyl alcohol(PVA),carboxymethyl chitosan(CMCS)and sodium alginate(SA)were selected as raw materials.Silver was compounded into the PVA-CMCS-SA hydrogel,and the silver-loaded PVA-CMCS-SA hydrogel wound dressing was constructed based on 3D printing.The micro-morphology,mechanical properties,water absorption and moisture retention,biocompatibility,antibacterial properties and in vitro coagulation properties of hydrogel wound dressings were then studied.The results show that the hydrogel wound dressing prepared by 3D printing has good dimensional structural stability,good mechanical properties,and the tensile strength can reach about 1000 kPa,and both the cyclic stretching and cyclic compression properties are good.Because of the 3D printed grid structure,the 3D printed hydrogel wound dressing has good water absorption,moisture retention,in vitro clotting,air permeability and antibacterial properties.The highest antibacterial rate against Escherichia coli and Staphylococcus aureus can reach 64%and 54%.It has low cytotoxicity and good biocompatibility.The 3D printing method can combine the hydrogel with the band-aid,ensuring the practicability of the wound dressing.Studies have shown that 3D printed silver-loaded hydrogel PVA-CMCS-SA can be used as a good wound dressing material.

关 键 词：伤口敷料 纳米银 水凝胶 3D打印 抗菌 海藻酸钠 壳聚糖 聚乙烯醇 

分 类 号：TB324[一般工业技术—材料科学与工程]