儿童反复下呼吸道感染中应用阿莫西林-克拉维酸钾序贯治疗对其IgG、IgA水平的影响  

Effect of amoxicillin clavulanate potassium sequential therapy on IgG and IgA levels in children with recurrent lower respiratory tract infection

作　　者：张佳佳[1] 项红霞[1] 顾丽娜 Zhang Jiajia;Xiang Hongxia;Gu Lina(Wuxi Children's Hospital Affiliated to Nanjing Medical University,Wuxi,Jiangsu 214000,China)

机构地区：[1]南京医科大学附属无锡儿童医院,江苏无锡214000

出　　处：《首都食品与医药》2022年第24期71-74,共4页Capital Food Medicine

摘　　要：目的探讨阿莫西林-克拉维酸钾序贯疗法应用于儿童反复下呼吸道感染治疗中的临床效果.方法选择2021年1月-2022年1月就诊于南京医科大学附属无锡儿童医院的儿童反复下呼吸道感染患者112例,经随机数字表法将其分成参考组(56例)和研究组(56例).参考组通过阿莫西林-克拉维酸钾持续静滴方式进行治疗,研究组予以阿莫西林-克拉维酸钾序贯治疗,以静滴方式治疗至患儿病情趋于稳定后,改为口服阿莫西林-克拉维酸钾片治疗.观察两组疗效及不良反应发生情况,对比其炎症反应及体液免疫指标变化、康复进程及住院费用.结果研究组总有效率对比参考组差异不明显(P>0.05);研究组不良反应发生率较参考组低,差异明显(P<0.05);较之治疗前,两组治疗后血清C-反应蛋白(CRP)、降钙素原(PCT)水平明显更低,血清免疫球蛋白A(IgA)及血清免疫球蛋白G(IgG)水平明显更高,且治疗后研究组CRP与PCT较参考组低,IgG与IgA较参考组高,差异显著(P<0.05);研究组各症状消失时间、住院时间较参考组短,且住院费用较参考组少,对比差异显著(P<0.05).结论阿莫西林-克拉维酸钾序贯疗法不但能够确保良好的儿童反复下呼吸道感染治疗效果,减少不良反应,而且可缓解患者炎症反应,改善其体液免疫水平,并能缩短患者康复进程,减少住院费用.Ob jective To explore the clinical effect of amoxicllin clavulanate potassium sequential therapy in the treatment of children with recurrent lower respiratory tract infection.Methods 112 children with recurrent lower respiratory tract infection who were hospitalized in our hospital from January 2021 to January 2022 were selected.The reference group(56cases)and the study group(56cases)were set up by random number table method.The reference group was treated with continuous intravenous drip of amoxicillin clavulanate potassium,and the study group was treated with sequential therapy of amoxicillin clavulanate potassium.After the children's condition stabilized by intravenous drip,they were treated with oral amoxicillin clavulanate potassium tablets.The curative effect and adverse reactions of the two groups were observed,and the changes of inflammatory reaction and humoral immune indexes,rehabilitation process and hospitalization penses were compared.Results The total effective rate of the study group was not significantly different from that of the reference group(P>0.05);the incidence of adverse reactions in the study group was significantly lower than that in the reference group(P<0.05);compared with before treatment,the levels of serum C-reactive protein(CRP)and procalcitonin(PCT)in the two groups after treatment were significantly lower,and the levels of serum immunoglobulin A(IGA)and serum immunoglobulin G(IgG)were significantly higher.After treatment,CRP and PCT in the study group were lower than those in the reference group,and IgG and IgA were higher than those in the reference group,with significant difference(P<0.05):the disappearance time and hospitalization time of symptoms in the study group were shorter than those in the reference group,and the hospitalization expenses were less than those in the reference group,with significant difference(P<0.05).Conc lusion Amoxicllin clavulanate potassium sequential therapy can not only ensure a good treatment effect for children with recurrent lower respiratory tr

关 键 词：儿童反复下呼吸道感染 阿莫西林克拉维酸钾 序贯疗法 血清免疫球蛋白A(IgA) 血清免疫球蛋白G(IgG) 

分 类 号：R725.6[医药卫生—儿科]