作用于细菌群体感应系统的中药单体  

Chinese Medicine Monomers Acting on Bacterial Quorum Sensing System

作　　者：曾利 凌保东[2] Zeng Li;Ling Baodong(School of Pharmacy,Chengdu Medical College,Chengdu 610500;Sichuan Province College Key Laboratory of Structure-Specific Small Molecule Drugs,Chengdu Medical College,Chengdu 610500)

机构地区：[1]成都医学院药学院,成都610500 [2]成都医学院结构特异性小分子药物研究四川省高校重点实验室,成都610500

出　　处：《中药药理与临床》2022年第5期229-233,共5页Pharmacology and Clinics of Chinese Materia Medica

基　　金：国家自然科学基金面上项目(编号:81373454)。

摘　　要：通过文献研究法归纳梳理具有抗细菌群体感应系统的中药单体及抗菌药物,探讨中药单体及联合抗菌药物抗细菌群体感应系统的研究进展。无论是细菌生物被膜的形成,还是细菌耐药性的增加,群体感应在其中扮演重要的角色,而中药单体丁香酚、小檗碱和槲皮素等是目前抗细菌群体感应系统研究的热点。中药单体通过影响细菌的群体感应系统,抑制生物被膜的形成和毒力因子的表达,与抗菌药物联合作用可恢复耐药菌对抗菌药物的敏感性,有望成为防治细菌感染性疾病的有效药物,同时也为生物被膜菌的清除提供新的途径和方法。Objective:To review Chinese medicine monomers and their combination with antibacterial drugs against bacterial quorum sensing system.Methods:Chinese medicine monomers and antibacterial drugs acting on bacterial quorum sensing system were summarized by literature research.Results:Quorum sensing plays an important role in both the formation of bacterial biofilm and bacterial resistance enhancement.At the moment,research on Chinese medicine monomers with anti-bacterial quorum sensing system effect focuses on eugenol,berberine,and quercetin.Conclusion:Chinese medicine monomers can inhibit the biofilm formation and the virulence factor expression of bacteria by affecting the quorum sensing system.In addition,they,by combining with antibacterial drugs,can restore the sensitivity of bacteria to the latter.Therefore,these monomers are expected to be candidate drugs for prevention and treatment of bacterial infections and add approaches for the clearance of biofilm-producing bacteria.

关 键 词：中药单体 抗菌药物 细菌群体感应 细菌生物被膜 

分 类 号：R284.1[医药卫生—中药学]