中医药调控慢传输型便秘Cajal间质细胞表达研究进展  

Research Progress of TCM Regulating the Expression of ICCs in Slow Transit Constipation

作　　者：姜洪宇 陈萌[2] 于永铎[1] JIANG Hongyu;CHEN Meng;YU Yongduo(Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China;The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110003,Liaoning,China)

机构地区：[1]辽宁中医药大学,辽宁沈阳110847 [2]辽宁中医药大学附属第三医院,辽宁沈阳110003

出　　处：《辽宁中医药大学学报》2022年第11期118-122,共5页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金青年科学基金(81804094);辽宁省科技厅自然基金(2019-MS-228)。

摘　　要：随着人们生活水平的提高以及泻药的广泛滥用,慢传输型便秘(STC)的发病率越来越高,增加了心脑血管等疾病猝发的风险并危及生命,还可以导致肛裂、内痔、肠梗阻等肛门直肠疾病的发生,其对人们生活质量的影响甚大。目前STC的发病机制并不十分明确,但越来越多地研究表明STC的发病机制与结肠组织内Cajal间质细胞(ICCs)关系密切,表现为STC患者体内ICCs的数目与结构均出现了不同程度上的改变,目前研究其影响ICCs数目与结构变化主要与C-kit/SCF相关通路、线粒体未折叠蛋白反应与Wnt-Retromer信号通路、ICCs的过度自噬等密切相关。中药与针刺疗法可通过对上述通路的调节作用,进而影响ICCs数目与结构的变化,具有多靶点、全身调节的特点,其疗效确切,不良反应较少。文章搜集近5年内关于慢传输型便秘机制及中医药对ICCs的表达作用相关文献,期望对STC发病机制的深入研究起到帮助作用。With the improvement of people’s living standard and the widespread abuse of laxatives,the incidence rate of STC is increasing,aggravating the risk of sudden cardiac and cerebrovascular diseases and endangering life,and also leading to anorectal diseases such as anal fissure,internal hemorrhoids and intestinal obstruction,which has great influence on people’s quality of life. At present,the pathogenesis of STC is not very clear,but more and more studies have shown that the pathogenesis of STC is closely related to Cajal stromal cells(ICCs)in colon tissue. The number and structure of ICCs in patients with STC have changed to varying degrees. At present,the research on its influence on the number and structure of ICCs is mainly related to C-kit/SCF pathway Mitochondrial unfolded protein response is closely related to Wnt retromer signaling pathway and excessive autophagy of ICCs. Traditional Chinese medicine and acupuncture can affect the changes of the number and structure of ICCs through the regulation of the above pathways. It has the characteristics of multi-target and systemic regulation. It has definite curative effect and less adverse reactions. This paper collects the relevant literature on the mechanism of slow transit constipation and the expression of traditional Chinese medicine on ICCs in recent 5 years,hoping to help the in-depth study of the pathogenesis of STC.

关 键 词：中药 慢传输型便秘 CAJAL间质细胞 C-kit/SCF信号通路 

分 类 号：R256.35[医药卫生—中医内科学]