广东省惠州市健康人群麻疹、风疹和流行性腮腺炎抗体水平调查  

Investigation of antibody levels of measles,rubella and mumps in Huizhou,Guangdong province

作　　者：李丽[1] 王莹[1] 严琦瑞[1] 刘燕[1] 方巧云[1] LI Li;WANG Ying;YAN QiRui;LIU Yan;FANG Qiaoyun(Huizhou Center for Disease Control and Prevention,Huizhou,Guangdong 516000,China)

机构地区：[1]惠州市疾病预防控制中心,广东惠州516000

出　　处：《河南预防医学杂志》2022年第12期939-942,共4页Henan Journal of Preventive Medicine

基　　金：惠州市科技计划项目(2019Y130)。

摘　　要：目的了解惠州市健康人群麻疹、风疹、流行性腮腺炎(流腮)抗体水平,查找免疫薄弱环节,为控制相应疾病提供参考和依据。方法采用分阶段抽样,第一阶段在惠州市每个县(区)随机抽取1个医疗机构作为调查点,第二阶段在每个调查点按8个年龄组分层随机抽样,按照估算样本量,在健康体检人群中抽取389名作为调查对象,用酶联免疫吸附试验(ELISA)定量检测麻疹、风疹、流腮Ig G抗体水平。结果389名调查对象麻疹、风疹、流腮Ig G抗体总阳性率分别为86.89%、77.12%和84.84%,Ig G抗体几何平均浓度(GMC)分别为704.00 m IU/m L、43.53 IU/m L、390.94 U/m L。其中,麻疹、风疹、流腮Ig G抗体阳性率及GMC均是0岁组最低,分别为46.67%、40.00%、40.00%和342.82 m IU/m L、16.55 IU/m L、125.34 U/m L;其次是7~14岁组,麻疹和风疹Ig G抗体阳性率仅分别为78.46%和61.54%,不同年龄组间麻疹、风疹、流腮Ig G抗体阳性率(χ^(2)_(麻疹)=64.859,χ^(2)_(风疹)=52.765,χ^(2)_(流腮)=57.230,P均<0.001)及GMC(H麻疹=64.504,H风疹=53.844,H流腮=22.521,P均<0.05)差异均有统计学意义。不同免疫史人群比较,未接种疫苗(免疫史0剂次)人群麻疹、风疹、流腮Ig G抗体阳性率及GMC均最低,分别是62.79%、50.00%、54.10%和460.91 m IU/m L、26.15 IU/m L、184.95 U/m L,不同免疫史人群间麻疹、风疹、流腮Ig G抗体阳性率差异均有统计学意义(χ^(2)_(麻疹)=29.127,χ^(2)_(风疹)=24.399,χ^(2)_(流腮)=54.827,P均<0.05)。结论0岁和7~14岁组是惠州市麻疹、风疹和流腮免疫薄弱人群。应积极开展查漏补种工作,提高疫苗接种的及时性及覆盖率;提倡育龄期妇女接种相关疫苗;定期开展抗体水平监测,及时掌握免疫薄弱人群。Objective To investigate the antibody levels of measles,rubella and mumps(mumps)in the whole population of Huizhou city,and find out the weak links of immunity,so as to provide reference and basis for the control of corresponding diseases.Methods The method of multi-stage random sampling was used;at the first stage in every county(district)of Huizhou a medical institution was selected in a random as investigation site;at the second phase in each investigation site according to stratified random sampling in the eight age groups,389 healthy people were randomly selected as investigation subjects.Enzyme immunosorbent test was employed for quantitative detection of Ig G antibody levels of measles,rubella,mumps.Results The overall positive rates of measles,rubella and mumps Ig G antibodies in 389 subjects were 86.89%,77.12%and 84.84%,respectively.The geometric mean concentration(GMC)of Ig G antibodies was 704.00 m IU/m L for measles,43.53 IU/m L for rubella and 390.94 U/m L for mumps.The positive rates of measles,rubella and mumps Ig G antibody and GMC of Ig G antibody were lowest in the0-year-old group,which were 46.67%,40.00%,40.00%and 342.82 m IU/m L,16.55 IU/m L,125.34 U/m L,respectively.The next age group was the 7-14-year-old group with respective positive rates of measles and rubella Ig G antibody of 78.46%and 61.54%.There were significant differences in the positive rates of measles,rubella and mumps Ig G antibodies and GMC of Ig G antibodies among different age groups(χ^(2)=64.859,χ^(2)=52.765,χ^(2)=57.230,all P<0.05;H=64.504,H=53.844,H=22.521,all P<0.05).The positive rates of measles,rubella and mumps Ig G antibody and GMC of Ig G antibody were the lowest in the population with 0 doses of measles,rubella and mumps vaccine,which were 62.79%,50.00%,54.10%and 460.91m IU/m L,26.15IU/m L,184.95U/m L,respectively.There were significant differences in the positive rates of measles,rubella and mumps Ig G antibodies among people with different immunological histories(χ^(2)=29.127,χ^(2)=24.399,χ^(2)=54.827,all P

关 键 词：麻疹 风疹 流行性腮腺炎 抗体水平 

分 类 号：R186[医药卫生—流行病学]