基于数据挖掘对中医药治疗围绝经期综合征用药规律的研究  

Analysis of medication rules of TCM for perimenopausal syndrome based on literature mining

作　　者：高敏 杨颖博[1,2] 林莉 应灵煊 孙连娜 肖伟 GAO Min;YANG Yingbo;LIN Li;YING Lingxuan;SUN Lianna;XIAO Wei(Chinese Medicine Research Institute,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Jiangsu Kanion Pharmaceutical Co.,Ltd.,Lianyungang 222001,China;College of Traditional Chinese Materia Medica,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学中药研究所,上海201203 [2]江苏康缘药业股份有限公司,江苏连云港222001 [3]上海中医药大学中药学院,上海201203

出　　处：《药学实践与服务》2023年第1期31-35,共5页Journal of Pharmaceutical Practice and Service

基　　金：江苏省工信厅2020年度工业和信息产业转型升级专项资金项目(多组分中药研究关键技术);上海中医药大学大学生创新创业训练计划项目更年颗粒质量标准研究资助(202110268042)。

摘　　要：目的探究中医药治疗围绝经期综合征(PMS)的用药规律,为PMS的临床治疗提供理论依据。方法检索了中国知网(CNKI)、万方数据库和维普数据库中近20年PMS相关文献,对治疗PMS的中药复方进行筛选,建立了相关数据库,并采用SPSS 20.0软件进行数据分析。结果筛选出文献含中药方剂/中成药184首,中药122味,药物类别以补虚药、清热药、收涩药、安神药为主;核心单味中药有白芍、熟地黄、当归、茯苓等;性味涵盖甘、苦、寒等;归经多属肝、肾、心、肺、脾经。对出现的高频中药进行聚类分析共得到2个主要组合。结论中医药治疗PMS以疏肝益气、滋肾养血宁心为重中之重,再根据临证配伍安神、清热利湿等药物;其临床治疗药物多为逍遥散、六味地黄丸、知柏地黄汤等方剂加减化裁。Objective To investigate the rules of Traditional Chinese Medicine in the treatment of perimenopausal syndrome(PMS)and provide a theoretical basis for the clinical treatment of PMS.Methods The literature related to PMS were collected from China Knowledge Network(CNKI),Wanfang database and Weipu database in the past 20 years,the herbal compound prescriptions for the treatment of PMS were screened and a relevant database were established and analyzed by SPSS.Results The relevant literatures contains 184 Chinese medicine prescriptions/proprietary Chinese medicines,122 flavors of traditional Chinese medicines,and the drug categories were mainly tonic drugs,antipyretic drugs,astringent drugs,and tranquilizers.The core single-flavor Chinese medicines were Baishao(Radix Paeoniae Alba),Shudihuang(Rehmannia glutinosa),Danggui(Radix Angelicae Sinensis),Fuling(Indian Buead).The property and flavor covered sweet,bitter,cold,etc.;and the channel tropism belonged to the liver,kidneys,heart,lungs,spleen and meridians.The cluster analysis of high-frequency Traditional Chinese Medicine obtained two main combinations.Conclusion TCM treatment of PMS focused on replenishing qi,soothing the liver,nourishing the kidneys,nourishing blood and calming the heart,and then according to clinical compatibility with drugs such as soothing the nerves,clearing heat and removing dampness;most of its clinical treatment were Xiaoyaosan,Liuwei Dihuang pills,and Zhibo Rehmanniae decoction and other prescriptions which were added and subtracted.

关 键 词：围绝经期综合征 中医药 数据挖掘 用药规律 

分 类 号：R271.9[医药卫生—中西医结合]