坚骨胶囊联合阿仑膦酸钠对老年骨质疏松患者骨密度及血清酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白eta、炎症指标的影响  

Effect of Jiangu capsule combined with alendronate sodium on bone mineral density and serum YWHAH and inflammation indexes in elderly patients with osteoporosis

作　　者：郝泽普[1] 武晔[2] 王晓磊[3] 张伟[1] HAO Zepu;WU Ye;WANG Xiaolei;ZHANG Wei(Department of imaging,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061001,China;the Fourth Department of Traumatic Orthopedics,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061001,China;the Second Department of Rheumatism,Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou 061001,China)

机构地区：[1]河北省沧州中西医结合医院影像一科,河北沧州061001 [2]河北省沧州中西医结合医院创伤骨四科,河北沧州061001 [3]河北省沧州中西医结合医院风湿二科,河北沧州061001

出　　处：《分子影像学杂志》2023年第1期98-102,共5页Journal of Molecular Imaging

基　　金：河北省中医药管理局中医药类科研计划项目(2021297)。

摘　　要：目的探讨坚骨胶囊联合阿仑膦酸钠对老年骨质疏松患者骨密度及血清酪氨酸3-单加氧酶/色氨酸5-单加氧酶激活蛋白eta(YWHAΗ)、炎症指标的影响。方法选取98例老年骨质疏松患者,以随机数字表法将其分为对照组(n=49)与观察组(n=49),对照组口服阿仑膦酸钠治疗,观察组在对照组的基础上加服坚骨胶囊。6月后比较两组骨密度、中医证候积分、疼痛程度及血清YWHAH、骨钙素、碱性磷酸酶、肿瘤坏死因子-α、白细胞介素-6水平。结果治疗后,两组腰椎、股骨颈骨密度高于治疗前、观察组高于对照组(P<0.05);两组中医证候积分低于治疗前、观察组低于对照组(P<0.05);两组静息及活动视觉模拟评分低于治疗前、观察组低于对照组(P<0.05);两组血清YWHAH水平低于治疗前、观察组低于及对照组(P<0.05);两组血清骨钙素水平高于治疗前、观察组高于对照组(P<0.05),两组血清碱性磷酸酶水平低于治疗前、观察组低于对照组(P<0.05);两组肿瘤坏死因子-α及白细胞介素-6低于治疗前、观察组低于对照组(P<0.05)。结论阿仑膦酸钠的基础上联合坚骨胶囊可有效提升老年骨质疏松患者骨密度、缓解疼痛,其机制可能与下调血清YWHAΗ水平、改善骨代谢指标、减轻炎症反应相关。Objective To investigate the effects of Jiangu capsule combined with alendronate sodium on bone mineral density,serum tyrosine YWHAH and inflammatory indexes in elderly patients with osteoporosis.Methods Ninety-eight elderly patients with osteoporosis were selected,and they were divided into control group(n=49)and observation group(n=49)by random number table method.The control group was treated with alendronate sodium,and the observation group was given Jiangu capsule on the basis of the control group.After 6 months,bone mineral density,TCM syndrome score,pain intensity and serum levels of YWHAH,osteocalcin,alkaline phosphatase,TNF-αand IL-6 were compared between the two groups.Results After treatment,the bone mineral density of lumbar vertebra and femoral neck in two groups were higher than that before treatment(P<0.05).After treatment,the TCM syndrome score of the observation group was lower than that before treatment.After treatment,the resting and activity VAS scores of the observation group was lower than that before treatment(P<0.05).After treatment,the level of serum YWHAH in the observation group was lower than that before treatment(P<0.05).After treatment,the serum osteocalcin level in the observation group was higher than that before treatment(P<0.05),and the serum alkaline phosphatase level in the observation group was lower than that before treatment(P<0.05).After treatment,TNF-αand IL-6 in the observation group was lower than that before treatment(P<0.05).Conclusion On the basis of alendronate sodium,combined with Jiangu capsule can effectively improve bone mineral density and relieve pain in elderly patients with osteoporosis.The mechanism may be related to down-regulating serum YWHAH level,improving bone metabolism indexes and alleviating inflammatory response.

关 键 词：坚骨胶囊 阿仑膦酸钠 骨质疏松 老年 骨密度 YWHAΗ 炎症 

分 类 号：R580[医药卫生—内分泌]