雪上一枝蒿化学成分及其生物活性的研究进展  

Chemical components and biological activities of Aconitum brachypodum Diels:a review

作　　者：韦鹏威 杨宇婷 王聪 刘红美[1,2] 王兵[1,2] WEI Pengwei;YANG Yuting;WANG Cong;LIU Hongmei;WANG Bing(Engineering Research Center of Medical and Pharmacy Biotechnology,Guizhou Medical University,Guiyang 550025,China;Key Laboratory of Biology and Medical Engineering,Guizhou Medical University,Guiyang 550025,China;School of Pharmacy,Guizhou Medical University,Guiyang 550025,China)

机构地区：[1]贵州医科大学医药生物技术工程研究中心,贵州贵阳550025 [2]贵州医科大学生物与医学工程重点实验室,贵州贵阳550025 [3]贵州医科大学药学院,贵州贵阳550025

出　　处：《生物加工过程》2022年第6期637-650,共14页Chinese Journal of Bioprocess Engineering

基　　金：国家自然科学基金青年项目(3220015);贵州省科技支撑计划(黔科合支撑[2020]4Y237);贵阳市科技计划(筑科合同[20151001]社15、黔科合基础[2019]1273);贵州医科大学博士启动基金(Academy-PHD-J-2014-018);贵州省卫健委科学计划(gzwjkj2015-1-028);贵阳市政府贵州医科大学联合基金(筑科合同[20161001]023、筑科合同[2017]5-26);贵州省大学生创新创业重点项目(201510660003)。

摘　　要：雪上一枝蒿为云南、四川等地民间常用药材,被用于治疗风湿疼痛、跌打损伤等症,主要成分为生物碱。其毒性剧烈,但在镇痛方面有显著疗效,具有重要的药用价值。主要从雪上一枝蒿的化学成分、炮制减毒、抗肿瘤、抗炎及抗菌作用等方面对其进行综述,以期为雪上一枝蒿的深入研究及其应用提供一定的理论基础和研究方向。Aconitum brachypodum Diels is a folk medicine in Yunnan and Sichuan in China.It is often used to treat rheumatic pain and bruise.Its main component is alkaloid.It has strong toxicity,significant effect on analgesia with important medicinal value.Here we review,the chemical constituents of Aconitum brachypodum Diels,its processing and antitumor,anti-inflammation,antimicrobial effects.The review provides basis reference for the application and more in-depth study of Aconitum brachypodum Diels in the future.

关 键 词：雪上一枝蒿 化学成分 抗菌 毒性 生物活性 

分 类 号：Q969.92[生物学—昆虫学]