苏桔口服液治疗小儿脾虚痰湿型久咳的临床疗效观察  

Clinical Study of Su Jie Oral Liquid for the Treatment of Pediatric Chronic Cough of Spleen Deficiency and Phlegm-damp Syndrome Type

作　　者：梁妙珍 程浣彤 李雪娇 林晓洁[2] LIANG Miao-Zhen;CHENG Huan-Tong;LI Xue-Jiao;LIN Xiao-Jie(Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;Guangdong Second Traditional Chinese Medicine Hospital,Guangzhou 510095 Guangdong,China)

机构地区：[1]广州中医药大学,广东广州510405 [2]广东省第二中医院,广东广州510095

出　　处：《广州中医药大学学报》2022年第11期2554-2557,共4页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】观察苏桔口服液治疗小儿脾虚痰湿型久咳的临床疗效。【方法】将100例脾虚痰湿型久咳患儿随机分为对照组和治疗组,每组各50例。对照组给予孟鲁司特钠咀嚼片治疗,治疗组给予苏桔口服液(由紫苏子、桔梗、紫菀、款冬花、法半夏等中药组成)治疗,疗程为2周。观察2组患儿治疗前后中医证候积分的变化情况,并评价2组患儿的疗效和安全性。【结果】(1)研究过程中,治疗组和对照组各有2例和4例患儿脱落,最终治疗组完成48例,对照组完成46例。(2)治疗2周后,治疗组和对照组的总有效率分别为93.75%(45/48)、80.43%(37/46);组间比较,治疗组的总有效率(卡方检验)和总体疗效(秩和检验)均明显优于对照组,差异均有统计学意义(P<0.05)。(3)治疗后,2组患儿的中医证候积分均较治疗前明显降低(P<0.01),且治疗组的降低作用明显优于对照组,组间治疗后及治疗前后差值比较,差异均有统计学意义(P<0.05)。(4)治疗过程中,2组患儿均未发生明显的不良反应事件,具有较高的安全性。【结论】苏桔口服液治疗小儿脾虚痰湿型久咳疗效显著,使用安全。Objective To observe the clinical efficacy of Su Jie Oral Liquid for the treatment of pediatric chronic cough of spleen deficiency and phlegm-damp syndrome type.Methods One hundred cases of children with chronic cough of spleen deficiency and phlegm-damp syndrome type were randomly divided into a control group and a treatment group,with 50 cases in each group.The control group was treated with Montelukast Sodium chewable tablets,while the treatment group was administrated with Su Jie Oral Liquid(mainly composed of Chinese herbs such as Fructus Perillae,Radix Platycodonis,Radix Asteris,Flos Farfarae and Rhizoma Pinelliae Preparatum).The treatment for the two groups lasted for 2 weeks.The changes in the TCM syndrome scores of the children in the two groups were observed before and after treatment,and then the clinical efficacy and safety of the two groups were evaluated.Results(1)During the trial,2 children in the treatment group and 4 children in the control group fell off,and 48 cases in the treatment group and 46 cases in the control group eventually completed the trial.(2)After 2 weeks of treatment,the overall effective rate of the treatment group was 93.75%(45/48)and that of the control group was 80.43%(37/46).The intergroup comparison showed that the overall effective rate(by Chi-square test)and overall efficacy(by rank sum test)of the treatment group were significantly superior to those of the control group,and the differences were statistically significant(P<0.05).(3)After treatment,the TCM syndrome scores in both groups were significantly decreased compared with those before treatment(P<0.01).The effect on lowering the TCM syndrome scores in the treatment group was significantly superior to that in the control group,and statistically significant difference was shown in the post-treatment scores and in the pre-and post-treatment difference of scores between the two groups(P<0.05).(4)During the treatment,there were no significant adverse events occurring in the two groups,and the therapy has high safety.Conc

关 键 词：苏桔口服液 小儿久咳 脾虚痰湿型 临床疗效 安全性 

分 类 号：R256.11[医药卫生—中医内科学]