益肾通督泻浊法治疗Ⅲ型慢性前列腺炎临床疗效观察  

Observation on the Clinical Efficacy of Therapy of Nourishing Kidney,Dredging Governor Vessel and Purging Turbidity for the Treatment of TypeⅢChronic Prostatitis

作　　者：齐君涛 陈棉雄 黄达坤 王亚东 刘尚文 林峰[2] QI Jun-Tao;CHEN Mian-Xiong;HUANG Da-Kun;WANG Ya-Dong;LIU Shang-Wen;LIN Feng(The Forth Clinical Medical School of Guangzhou University of Chinese Medicine,Shenzhen 518033 Guangdong,China;Surgical WardⅡ,Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033 Guangdong,China)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]深圳市中医院外二科,广东深圳518033

出　　处：《广州中医药大学学报》2022年第12期2799-2804,共6页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：广东省中医药局科研项目(编号:20201308)。

摘　　要：【目的】观察运用益肾通督泻浊法治疗Ⅲ型慢性前列腺炎(亦称为慢性盆腔疼痛综合征,CP/CPPS)的临床疗效。【方法】将100例脾肾亏虚型CP/CPPS患者随机分为观察组和对照组,每组各50例。对照组给予盐酸坦索罗辛缓释胶囊治疗,观察组在对照组的基础上给予口服基于益肾通督泻浊法组方的前列益肾方(由熟地黄、山茱萸、山药、菟丝子、巴戟天等中药组成)治疗,疗程为4周。观察2组患者治疗前后美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分、中医证候评分及尿流动力学指标的变化情况,并在治疗结束后对2组患者的临床疗效进行评估。【结果】(1)治疗4周后,观察组和对照组的总有效率分别为88.0%(44/50)和72.0%(36/50),组间比较,观察组的总体疗效(Mann-Whitney U秩和检验)和总有效率(卡方检验)均明显优于对照组(P<0.05)。(2)治疗后,2组患者的NIH-CPSI评分均较治疗前明显降低(P<0.01),且观察组对NIH-CPSI评分的降低作用明显优于对照组(P<0.01)。(3)治疗后,2组患者的尿路症状、疼痛症状、性功能障碍、全身症状等中医证候评分及总评分均较治疗前明显降低(P<0.01),且观察组对尿路症状、疼痛症状、全身症状评分及总评分的降低作用均明显优于对照组(P<0.05)。(4)治疗后,2组患者的尿流动力学指标最大尿流率(MFR)和平均尿流率(AFR)均较治疗前改善(P<0.01),且观察组对尿流动力学指标MFR、AFR的改善作用均明显优于对照组(P<0.05)。【结论】运用益肾通督泻浊法治疗CP/CPPS疗效显著,可有效改善患者下尿路症状、疼痛症状以及尿流率。Objective To observe the clinical efficacy of therapy of nourishing kidney,dredging Governor Vessel and purging turbidity in treating typeⅢchronic prostatitis(CP),also known as chronic pelvic pain syndrome(CPPS).Methods A total of 100 CP/CPPS patients were randomized into observation group and control group,with 50 cases in each group.The control group was treated with Tamsulosin Hydrochloride Sustained-Release Capsules,while the observation group was administrated with Chinese herbal medicine of Qianlie Yishen Prescription(mainly composed of Radix Rehmanniae Preparata,Fructus Corni,Rhizoma Dioscoreae,Semen Cuscutae and Radix Morindae Officinalis)on the basis of treatment for the control group.Both groups were administrated for 4 weeks.The changes in the National Institutes of Health Chronic Prostatitis Symptom Index(NIH-CPSI)scores,traditional Chinese medicine(TCM)syndrome scores,and urodynamic parameters in the two groups were observed before and after treatment.After treatment,the clinical efficacy of the two groups was evaluated.Results(1)After 4 weeks of treatment,the total effective rate of the observation group was 88.0%(44/50)and that of the control group was 72.0%(36/50).The intergroup comparison showed that the overall efficacy(by Mann-Whitney U rank sum test)and overall effective rates(by Chi-square test)of the observation group were significantly superior to that of the control group(P<0.05).(2)After treatment,the NIH-CPSI scores in both groups were significantly decreased compared with those before treatment(P<0.01),and the effect of the observation group on decreasing NIH-CPSI scores was significantly stronger than that of the control group(P<0.01).(3)After treatment,the scores of TCM symptoms of urinary tract symptoms,pain symptoms,sexual dysfunction,and systemic symptoms as well as the total scores of TCM syndrome in both groups were significantly decreased compared with those before treatment(P<0.01),and the effect on lowering the scores of urinary tract symptoms,pain symptoms and systemic symp

关 键 词：益肾通督泻浊法 前列益肾方 Ⅲ型慢性前列腺炎(慢性盆腔疼痛综合征 CP/CPPS) 美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分 中医证候评分 尿流动力学 

分 类 号：R277.5[医药卫生—中医学]