中药外用治疗急性软组织损伤用药规律文献研究及其核心药物乳香-没药网络药理学机制分析  

Literature Study on the Medication Rules of External Application of Chinese Medicine for the Treatment of Acute Soft Tissue Injury and Network Pharmacology Analysis of the Therapeutic Mechanism of the Core Herbal Pair of Olibanum and Myrrha

作　　者：何富平 李亨[2] 谢辉 蒋顺琬[2] HE Fu-Ping;LI Heng;XIE Hui;JIANG Shun-Wan(The Fourth Clinical Medical School of Guangzhou University of Chinese Medicine,Shenzhen 518033 Guangdong,China;Shenzhen Traditional Chinese Medicine Hospital,Shenzhen 518033 Guangdong,China)

机构地区：[1]广州中医药大学第四临床医学院,广东深圳518033 [2]深圳市中医院,广东深圳518033

出　　处：《广州中医药大学学报》2022年第12期2965-2973,共9页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：深圳市科技创新委员会项目(编号:JCYJ20180302173610088)。

摘　　要：【目的】基于现代数据挖掘技术分析中药外用治疗急性软组织损伤的用药规律,并阐释核心药物潜在的作用机制,为临床治疗急性软组织损伤提供依据。【方法】检索中国知网(CNKI)、万方数据(Wanfang Data)、维普中文科技期刊数据库(VIP)等数据库中收录的有关中药外用治疗急性软组织损伤的临床研究文献,构建方药数据库,对所得处方药物运用古今医案云平台(Version 2.3.5)分析其用药规律,筛选核心药物。对核心药物进行网络药理学的蛋白质-蛋白质相互作用(proteinprotein interaction,PPI)分析、基因本体(gene oncology,GO)功能富集分析和京都基因与基因组百科全书(Kyoto Encyclopedia of Genes and Genomes,KEGG)通路富集分析,以揭示其潜在的作用机制。【结果】共纳入文献478篇,药物350味。中药外用治疗急性软组织损伤的常用药物有大黄、红花、乳香、没药、当归、黄柏、栀子、冰片、白芷、血竭等;高频药物药性偏温,药味多辛苦,主要归肝、脾、心经。核心药对乳香-没药的潜在信号通路集中在PI3K-Akt信号通路、丝裂原活化蛋白激酶(MAPK)信号通路、核因子κB(NF-κB)信号通路及肿瘤坏死因子(TNF)信号通路。【结论】中药外用治疗急性软组织损伤多采用性温、味辛苦、归肝脾心经的行气散瘀、活血止痛的药物。核心药物乳香-没药治疗急性软组织损伤的潜在信号通路的揭示,可为中药的疗效机制研究提供思路。Objective To analyze the medication rules of external application of Chinese medicine for the treatment of acute soft tissue injury(ASTI)based on modern data mining technology,and to illustrate the potential therapeutic mechanism of core drugs,so as to provide a basis for the clinical treatment of ASTI.Methods The literatures on external application of Chinese medicine for ASTI were retrieved from the databases such as CNKI,Wanfang Data,and VIP,and then the databases of the related prescriptions and herbs were constructed.The ancient and modern medical case cloud platform(Version 2.3.5)was used to analyze the medication rule of the obtained prescriptions and herbs and to screen the core herbs.Protein-protein interaction(PPI)analysis,gene oncology(GO)functional enrichment analysis,and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis in the field of network pharmacology were performed on the core herbs to reveal their potential therapeutic mechanisms.Results A total of 478 articles with 350 herbs were included.The commonly-used herbs for external application in treating ASTI include Radix et Rhizoma Rhei,Flos Carthami,Olibanum,Myrrha,Radix Angelicae Sinensis,Cortex Phellodendri,Fructus Gardeniae,Borneolum Syntheticum,Radix Angelicae Dahuricae,and Sanguis Draconis.The high-frequency herbs were warm in the nature,pungent and bitter in the taste,and mainly had the meridian tropism of the liver,spleen and heart meridians.The potential signaling pathways of core herbal pair of Olibanum and Myrrha were associated with the PI3K-Akt signaling pathway,mitogen-activated protein kinase(MAPK)signaling pathway,nuclear factor kappa B(NF-κB)signaling pathway and tumor necrosis factor(TNF)signaling pathway.Conclusion In treating ASTI,Chinese medicine for external application usually has the actions of moving qi and removing blood stasis,activating blood and relieving pain,which are warm in the nature and pungent and bitter in the taste,and have the meridian tropism of liver,spleen and heart meridians.The d

关 键 词：急性软组织损伤 中药外用 行气散瘀 活血止痛 乳香 没药 数据挖掘 网络药理学 文献研究 

分 类 号：R285.5[医药卫生—中药学]