间充质干细胞的免疫调节可塑性及其临床应用策略  

Immunomodulatory plasticity of mesenchymal stem cells and the strategy of clinical application

作　　者：汪海燕 韩钦[1] 赵春华[1] WANG Haiyan;HAN Qin;ZHAO Chunhua(Center for Organizational Engineering,Institute of Basic Medical Sciences CAMS&School of Basic Medicine PUMC,Beijing 100005,China)

机构地区：[1]中国医学科学院基础医学研究所,北京协和医学院基础学院组织工程中心,北京100005

出　　处：《基础医学与临床》2023年第1期2-11,共10页Basic and Clinical Medicine

基　　金：国家自然科学基金(81971324,81902848)。

摘　　要：间充质干细胞(MSCs)是具有自我更新、多向分化和免疫调节能力的多能干细胞。越来越多的研究证明了MSCs在免疫紊乱相关疾病治疗中的有益作用。然而体内获取或体外培养的MSCs的免疫调节能力都存在异质性,MSCs的免疫调节能力也会受到微环境的调控。本综述概述MSCs的免疫抑制能力和免疫支持能力的机制,介绍最近关于MSCs免疫调节机制的研究及其免疫调节能力可塑性假说,并讨论在细胞生产阶段增强MSCs免疫调节能力的策略,以期为MSCs临床转化研究提供参考。Mesenchymal stem cells(MSCs)are pluripotent stem cells with self-renewal,multi-directional differentiation and immunoregulatory capabilities.More and more studies have demonstrated the beneficial role of MSCs in the treatment of immune disorders.However,there is heterogeneity in the immunoregulatory capacity of MSCs obtained in vivo or cultured in vitro,and the immunoregulatory capacity of MSCs is also regulated by the microenvironment.This review provides an overview of the mechanisms of the immunosuppressive and immune supportive abilities of MSCs,introduces recent studies on the immunoregulatory mechanisms of MSCs and the plasticity hypothesis of their immunoregulatory abilities,and discusses strategies to enhance the immunoregulatory abilities of MSCs in the cell production stage.This review aims to provide a reference for the clinical translational research of MSCs.

关 键 词：间充质干细胞(MSCs) 免疫调节 免疫调节能力的可塑性 

分 类 号：Q28[生物学—细胞生物学]