间充质干细胞外泌体治疗肺部疾病的研究进展  

Research advances in the treatment of lung diseases based on mesenchymal stem cell exosomes

作　　者：陈莉莉 孙永红[2] 雷晓燕[2] 王建军[2] 陈星星 鲍柏辛 CHEN Lili;SUN Yonghong;LEI Xiaoyan;WANG Jianjun;CHEN Xingxing;BAO Baixin(First College of Clinical Medicine,Gansu University Traditional Chinese Medicine,Lanzhou 730000;Department of Pediatrics,Gansu Provincial Peoples Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]甘肃省人民医院儿科,甘肃兰州730000

出　　处：《基础医学与临床》2023年第1期192-195,共4页Basic and Clinical Medicine

基　　金：甘肃省国际科技合作专项(18YF1WA040);甘肃省自然科学基金(20JR10RA385);甘肃省人民医院院内科研基金(19SYPYB-24,18GSSY3-4)。

摘　　要：间充质干细胞来源的外泌体(MSC-EXOs)携带着脂质、蛋白、核酸等信号物质,在细胞间通讯、免疫调节、血管再生中发挥着重大作用。MSC-EXOs在肺动脉高压、肺纤维化等肺部疾病中通过调控不同的信号通路、减少细胞炎性反应、调节免疫细胞功能、改善线粒体功能、促进血管生成、减轻肺血管重构等途径改善肺组织的功能,治疗肺部疾病,从而为今后难治性肺部疾病的治疗提供新思路。Exosomes secreted by mesenchymal stem cell(MSC-EXOs)carry lipids,proteins,nucleic acids and other signaling substances,which play an important role in intercellular communication,immune regulation and vascular regeneration.MSC-EXOs in pulmonary hypertension,pulmonary fibrosis and other lung diseases can improve the function of the lung tissue and treat lung diseases by regulating different signaling pathways,reducing cell inflammatory reaction,regulating immune function,improving the function of mitochondria,promoting angiogenesis,reducing pulmonary vascular remodeling and etc.,which provides new ideas for the treatment of refractory lung diseases in the future.

关 键 词：间充质干细胞 外泌体 肺部疾病 

分 类 号：R563[医药卫生—呼吸系统]