来曲唑联合尿促卵泡素治疗对多囊卵巢综合征不孕症患者FSH及LH的影响  

Effects of letrozole combined with urofollitropin on FSH and LH in infertile patients with polycystic ovary syndrome

作　　者：王莹莹[1] 赵路[1] 雷伟[1] 张梅[1] WANG Ying-ying;ZHAO Lu;LEI Wei;ZHANG Mei(Department of Pharmacy,Zhengzhou Maternal and Child Health Hospital,Zhengzhou 450012,China)

机构地区：[1]郑州市妇幼保健院药学部,郑州450012

出　　处：《医药论坛杂志》2022年第21期25-28,共4页Journal of Medical Forum

基　　金：2020年度河南省医学科技攻关项目(LHGJ20200740)。

摘　　要：目的探讨来曲唑联合尿促卵泡素治疗对多囊卵巢综合征(polycystic ovary syndrome,PCOS)不孕症患者的应用价值。方法选取2020年5月—2021年5月郑州市妇幼保健院PCOS不孕症患者98例,采用随机数字表法分为观察组49例、对照组49例。对照组采用来曲唑,观察组采用来曲唑联合尿促卵泡素。对比两组排卵率和妊娠率、优势卵泡数、促黄体生成素(LH)、促卵泡激素(FSH)水平、不良反应发生率及妊娠结局。结果观察组排卵率83.67%(41/49)、妊娠率75.51%(37/49),高于对照组[65.31%(32/49)、55.10%(27/49)](P<0.05);治疗后,观察组优势卵泡数较对照组多(P<0.05);治疗5 d后,观察组LH、FSH水平低于对照组(P<0.05);观察组不良反应发生率[8.16%(4/49)]与对照组[6.12%(3/49)]对比差异无统计学意义(P>0.05);观察组多胎妊娠率2.97%(1/37)、早期流产率0.00%(0/37),与对照组[7.41%(2/27)、3.70%(1/27)]对比无显著差异(P>0.05)。结论来曲唑联合尿促卵泡素治疗PCOS不孕症,可促进机体排卵,提高妊娠率,并可调节性激素水平,改善妊娠结局。Objective To explore the value of letrozole combined with urofollitropin in the treatment of infertility patients with polycystic ovary syndrome(PCOS).Methods A total of 98 infertility patients with PCOS in our hospital from May 2020 to May 2021 was selected and divided into an observation group of 49 cases and a control group of 49 cases by random number table method.The control group was given letrozole,and the observation group was given letrozole combined with urofollitropin.The ovulation rate,pregnancy rate,the number of dominant follicles,the levels of luteinizing hormone(LH)and follicle-stimulating hormone(FSH),the incidence of adverse reactions and the pregnancy outcome of the two groups were compared.Results The ovulation rate was 83.67%(41/49)and pregnancy rate was 75.51%(37/49)of the observation group which were both higher than those[65.31%(32/49)and 55.10%(27/49)]of the control group(P<0.05).After treatment,the dominant follicles number of the observation group was more than that of the control group(P<0.05).After 5 days of treatment,the LH and FSH levels of the observation group were both lower than those of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group(8.16%,4/49)and the control group(6.12%,3/49)(P>0.05).There were no significant differences between multiple pregnancy 2.97%(1/37)and early abortion 0.00%(0/37)in observation group with[7.41%(2/27)and 3.70%(1/27)]in control group(P>0.05).Conclusion Letrozole combined with urofollitropin in the treatment of PCOS infertility can promote ovulation,increase pregnancy rate,regulate sex hormone level and improve pregnancy outcome.

关 键 词：多囊卵巢综合征 不孕症 来曲唑 尿促卵泡素 

分 类 号：R711.6[医药卫生—妇产科学]