氧化硅基杂化胶束负载Flav7光热剂的合成与性能研究  

Flav7-loaded Silica-based Hybrid Micelles: Synthesis and Photothermal Performance

作　　者：池哲人 张辽 郭志前 李永生[1,3] 牛德超 CHI Zheren;ZHANG Liao;GUO Zhiqian;LI Yongsheng;NIU Dechao(School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China;School of Chemistry and Chemical Engineering,Shihezi University,Shihezi 832003,China)

机构地区：[1]华东理工大学材料科学与工程学院,上海200237 [2]华东理工大学化学与分子工程学院,上海200237 [3]石河子大学化学化工学院,石河子832003

出　　处：《无机材料学报》2022年第11期1236-1244,共9页Journal of Inorganic Materials

基　　金：国家自然科学基金(52072124);上海市自然科学基金(20ZR1414900)。

摘　　要：近年来,由于具有较好的近红外区吸收、结构可调等特点,有机小分子光热剂在生物医药领域展示出广阔的应用前景。然而,大部分有机小分子光热剂仍面临水溶性较差、生物稳定性不佳、光热转换效率较低等挑战。本研究发展了一种简便的合成方法,制备了负载Flav7的氧化硅基杂化胶束(FPOMs)用于高效的光热治疗。首先利用嵌段共聚物PS_(132)-b-PAA_(16)自组装行为负载疏水近红外有机小分子Flav7得到胶束体系,进一步引入3-巯基丙基三甲氧基硅烷(MPTMS)和聚乙二醇(PEG)对上述胶束体系进行结构固定和表面改性得到FPOMs。研究表明,在808 nm波长激光的激发下, FPOMs展现出优异的光热稳定性和较高的光热转换效率(46.7%)。细胞实验证实FPOMs具有良好的生物相容性和光热毒性,有望作为一类新型的纳米光热剂用于肿瘤高效安全光热治疗。Recently, organic small molecule photothermal agents have great application potentials in the field of biomedicine due to their high extinction coefficient in the near-infrared region and good structural tunability. Unfortunately, most current organic small molecular photothermal agents prove to be still poor water solubility, unsatisfactory biological stability, and low photothermal conversion efficiency. To address these, a simple method was developed to prepare Flav7-loaded silica-based hybrid micelles(FPOMs) for efficient photothermal therapy. Firstly, the Flav7-loaded micelles were prepared by self-assembly of block copolymer PS_(132)-b-PAA_(16). Then, 3-mercaptopropyl trimethoxysilane(MPTMS) and polyethylene glycol(PEG) were introduced to fix the structure and endowed the surface modification of the system, respectively, resulting in the final formation of FPOMs. Results show that FPOMs exhibit excellent photothermal stability and high photothermal conversion efficiency(46.7%) under the excitation of 808 nm laser. Cell experiments indicate that FPOMs have good biocompatibility and photothermal toxicity. It is highly expected to be used as a new type of nano-photothermal agent for efficient and safe photothermal therapy.

关 键 词：Flav7 氧化硅基材料 胶束 光热性能 

分 类 号：TQ138[化学工程—无机化工]