Bischler-Napieralski反应研究进展  

Progress in Bischler-Napieralski reaction

作　　者：陈洁忠[1] 余瑜[2] CHEN Jie-zhong;YU Yu(Nursing department,Jiyuan Vocational and Technical College,Jiyuan 459000,China;College of pharmaceutical science,Chongqing Medicinal University,Chongqing 400016,China)

机构地区：[1]济源职业技术学院护理系,河南济源459000 [2]重庆医科大学药学院,重庆400016

出　　处：《化学研究与应用》2023年第1期21-27,共7页Chemical Research and Application

基　　金：国家自然科学基金项目(30772595,30171070)资助。

摘　　要：Bischler-Napieralski反应是合成3,4-二氢异喹啉的经典方法。通过文献调研,对其机理、影响因素、拓展研究及应用进行综述,发现Bischler-Napieralski反应已被广泛运用于医药、化工等重要中间体的合成,但三氯氧磷、五氧化二磷等脱水剂的使用仍较频繁。Bischler-Napieralski reaction is a classical method of the synthesis of 3,4-dihydroisoquinolines.Through literature research,the mechanism,influencing factors,expanding research and application of Bischler-Napieralski reaction were reviewed.It was found that Bischler-Napieralski reaction had been widely used in the synthesis of important intermediates such as medicine and chemical industry.However,phosphorus oxychloride,phosphorus pentoxide and other dehydrating agents were still frequently used.

关 键 词：Bischler-Napieralski反应 3 4-二氢异喹啉 中间体 

分 类 号：O626.32[理学—有机化学]