快速响应氟离子反应型荧光探针的设计合成与光谱学研究  

Design,synthesis and spectroscopic study of fast fluoride-reactive fluorescent probes

作　　者：董萍 李丹 文兴莲 吴昊 刘力[1,2] 鄢龙家 DONG Ping;LI Dan;WEN Xing-liang;WU Hao;LIU Li;YAN Long-jia(School of Pharmacetutical Sciences,Guizhou University,Guiyang 550025,China;Guizhou Synthetic Drugs of Guizhou Province,Guiyang 550025,China)

机构地区：[1]贵州大学药学院,贵州贵阳550025 [2]贵州省合成药物工程实验室,贵州贵阳550025

出　　处：《化学研究与应用》2023年第1期66-74,共9页Chemical Research and Application

基　　金：贵州省科技计划项目(黔科合基础-ZK[2022]一般124)资助;全国大学生创新创业项目(贵大(国)创字2021(040))资助。

摘　　要：本文基于萘环和吩噻嗪环的荧光特性,设计合成了4个氟离子反应型荧光探针。通过研究其光物理性质发现,吩噻嗪环为荧光团的氟离子探针响应时间比萘环的短,在2 min内能快速响应氟离子。探针PSC响应氟离子后,不仅提高了探针灵敏度,还对常见的阴离子、阳离子和其他小分子等具有较强的抗干扰性。Based on the fluorescent properties of naphthalene and phenothiazine rings,four fluorescent probes were designed and synthesized in this paper for detection of fluoride ions.After studying the photophysical properties,it was found that the response time of the fluoride ions with the phenothiazine ring as the fluorophore was shorter than the naphthalene ring,and it could quickly respond to the fluoride ion within 2 min.The probe PSC could improve the sensitivity and strong anti-interference properties to common anions,cations and other small molecules.

关 键 词：氟离子 荧光探针 设计 合成 

分 类 号：O621.2[理学—有机化学]