25-羟基胆固醇的合成及路线优化  

Synthesis and route optimization of 25-hydroxycholesterol

作　　者：石维琦 程铖 汤磊 王建塔 陈文章 朱高峰 SHI Wei-qi;CHENG Cheng;TANG Lei;WANG Jian-ta;CHEN Wen-zhang;ZHU Gao-feng(College of Pharmacy,Guizhou Medical University,Guiyang 550004,China;Basic Medical College,Guizhou Medical University,Guiyang 550004,China;Guizhou Engineering Research Center of Chemical Synthetic Drugs,Guiyang 550004,China)

机构地区：[1]贵州医科大学药学院,贵州贵阳550004 [2]贵州医科大学基础医学院,贵州贵阳550004 [3]贵州省化学合成药物研发利用工程技术研究中心,贵州贵阳550004

出　　处：《化学研究与应用》2023年第1期222-227,共6页Chemical Research and Application

基　　金：贵州省普通高等学校科技拔尖人才支持计划项目(黔教合KY字[2017]072)资助;贵州省卫生健康委科学技术基金项目(gzwkj2022-469)资助。

摘　　要：以猪去氧胆酸为起始原料,经酯化、上保护、还原、氧化、缩合、水解、酯化、环氧化、还原等九步反应,制备25-羟基胆固醇,总收率30%。目标产物结构经^(1)HNMR和 ^(13)CNMR鉴定。Using Hyodeoxycholic acid as starting material,25-hydroxycholesterol had been achieved in nine steps via esterification,condensation,reduction,oxidation,hydrolysis,substitution with a total yield of 30%.And the final product was confirmed by ^(1)HNMR and ^(13)CNMR.

关 键 词：猪去氧胆酸 25-羟基胆固醇 合成 

分 类 号：O629.2[理学—有机化学]