非标准抗体在血清阴性抗磷脂综合征中的诊断价值  

Seronegative antiphospholipid syndrome:refining the value of“non-criteria”antibodies for diagnosis

作　　者：安然[1] 杨树艳[1] 刘磊(综述)[1] 李佩玲(审校)[2] AN Ran;YANG Shuyan;LIU Lei;LI Peiling(Department of Obstetrics and Gynecology,the Fourth Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150001,China;Department of Obstetrics and Gynecology,the Second Affiliated Hospital of Harbin Medical University,Harbin,Heilongjiang 150001,China)

机构地区：[1]哈尔滨医科大学附属第四医院妇产科,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第二医院妇产科,黑龙江哈尔滨150001

出　　处：《国际检验医学杂志》2023年第1期95-100,共6页International Journal of Laboratory Medicine

基　　金：国家自然科学基金(82072864)。

摘　　要：抗磷脂综合征(APS)是以血栓形成、病态妊娠为主要临床表现的自身免疫性疾病,实验室检测抗心磷脂抗体(aCLs)、抗β2-糖蛋白-Ⅰ抗体(抗β2-GPⅠ)和狼疮抗凝物(LA)。一些患者有APS临床表现,但典型抗磷脂抗体呈间断阳性或持续阴性,称之为血清阴性APS(SN-APS)。现阶段研究发现SN-APS患者可检出其他诊断标准外的抗体,如IgA型抗磷脂抗体、抗凝血酶原抗体、抗磷脂酰丝氨酸/凝血酶原复合物抗体、抗磷脂酰乙醇胺抗体等,故本文探讨此类抗体在血清阴性抗磷脂综合征中的诊断价值。Antiphospholipid syndrome(APS)is an autoimmune disease with thrombosis and morbid pregnancy as the main clinical manifestations of the diagnostic value of non-standard antibodies in serum negative antiphospholipid syndrome.Laboratory tests mainly include anticardiolipin antibodies(aCLs),β2 GlycoproteinⅠantibody(aβ2-GPⅠ)and lupus anticoagulant(LA).In some cases,patients may present with clinical features of APS but with temporary positive or persistently negative titers of aPLs.For these patients,the definition of seronegative APS(SN-APS)has been proposed.At this stage,it is found that SN-APS patients can detect antibodies beyond other diagnostic criteria,such as IgA type antiphospholipid antibody,antithrombin antibody,antiphospholipid serine/prothrombin complex antibody,antiphospholipid ethanolamine antibody,and so on.Therefore,this article discusses the diagnostic value of these antibodies in serum negative antiphospholipid syndrome.

关 键 词：抗磷脂综合征 抗磷脂抗体 诊断标准 

分 类 号：R593.2[医药卫生—内科学]