大鼠肝移植无肝期研究进展  

Research progress on anhepatic phase in rat liver transplantation

作　　者：韩田 张丽[1] 常庆尧 李想 贺晓鹏 闫哲宁 高琳 徐钧[1] Han Tian;Zhang Li;Chang Qingyao;Li Xiang;He Xiaopeng;Yan Zhening;Gao Lin;Xu Jun(Department of Hepatobiliary and Pancreatic Surgery,Liver Transplantation Center,the First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院肝胆胰外科暨肝移植中心,太原030001 [2]山西医科大学第一临床医学院 [3]山西医科大学麻醉学院 [4]山西医科大学影像学院

出　　处：《器官移植》2023年第1期142-146,共5页Organ Transplantation

基　　金：山西省卫生健康委员会科研项目(2020085、2022142、2020TD08);山西省科学技术厅中央引导地方专项基地课题(YDZJSX2021B012)。

摘　　要：随着肝移植手术器械、方法和技术不断发展,其疗效日益提升,但无肝期时间的长短仍是影响肝移植效果的重要因素。大鼠是肝移植相关基础研究的主要动物模型之一,本文就延长大鼠肝移植无肝期持续时间及缩短大鼠肝移植无肝期操作时间的方法,包括吸入性七氟烷麻醉、颈静脉留置针补液、无肝期前夹闭腹主动脉、无肝期前门静脉注入生理盐水、脾脏皮下转位术、肝食管动脉电凝离断、肝上下腔静脉磁环吻合、肝上下腔静脉套管吻合、肝上下腔静脉支架吻合、门静脉快速连接装置套管、肝下下腔静脉保留肝脏组织环套管进行综述,为延长大鼠无肝期持续时间,提高无肝期操作效率,提升大鼠肝移植成功率提供参考。With persistent advancement of surgical instruments,methods and techniques,clinical efficacy of liver transplantation has been steadily enhanced.However,the length of anhepatic phase is still an important factor affecting the efficacy of liver transplantation.Rat is one of the major animal models for liver transplantation-related basic research.In this article,multiple approaches for prolonging the anhepatic phase and shortening the operation time during anhepatic phase in rat liver transplantation were reviewed,which consisted of sevoflurane inhalation anesthesia,intravenous infusion via jugular vein indwelling needle,clamping of the abdominal aorta before anhepatic phase,injection of normal saline into portal vein before anhepatic phase,subcutaneous transposition of the spleen,electrocoagulation of hepatic esophageal artery,magnetic ring anastomosis of the superior and inferior hepatic vena cava,cannula anastomosis of the superior and inferior hepatic vena cava,stent anastomosis of the superior and inferior hepatic vena cava,rapid connection device and cannula of portal vein,and ring-shaped cannula of hepatic tissue-preserving inferior hepatic vena cava,aiming to add evidence for prolonging the duration of anhepatic phase,improving the operation efficiency during anhepatic phase and elevating the success rate of rat liver transplantation.

关 键 词：大鼠 肝移植 无肝期 下腔静脉 门静脉 补液 磁环吻合 支架吻合 套管吻合 

分 类 号：R617[医药卫生—外科学] R-33[医药卫生—临床医学]