肝静脉压力梯度对肝移植受者术前评估及预后预测的价值  

Value of hepatic venous pressure gradient in preoperative evaluation and prognosis prediction in liver transplant recipients

作　　者：张鹏飞 陈雅洁 曹经琳[1] 赵彩彦[2] 王洋[1] 窦剑[1] Zhang Pengfei;Chen Yajie;Cao Jinglin;Zhao Caiyan;Wang Yang;Dou Jian(Department of Hepatobiliary Surgery,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学第三医院肝胆外科,石家庄050051 [2]河北医科大学第三医院感染科,石家庄050051

出　　处：《器官移植》2023年第1期154-159,共6页Organ Transplantation

基　　金：2022年政府资助临床医学优秀人才培养项目;中国肝炎防治基金会2020年度天晴肝病研究基金项目(TQGB20200167);河北省人力资源和社会保障厅2020年度引进留学人员资助项目(C20200348)。

摘　　要：肝静脉压力梯度(HVPG)是诊断门静脉高压的“金标准”,可用于肝硬化的评估,与终末期肝病模型(MELD)评分系统联合应用能更精准地匹配肝硬化肝移植供受者,选择合适的手术时机,并为患者在等待肝移植期间的桥接治疗提供指导。除此之外,HVPG也能预测肝移植受者的预后,并为可能出现的并发症提供早发现、早干预的依据。因此,本文通过对HVPG在肝移植受者术前评估及预后预测的价值进行综述,以期为临床肝移植受者术前和术后的诊疗提供指导。Hepatic venous pressure gradient(HVPG)is the“gold standard”for the diagnosis of portal hypertension,which could be applied in the evaluation of liver cirrhosis.Combined use of HVPG with model for endstage liver disease(MELD)scoring system may more accurately match the donors and recipients undergoing liver transplantation for liver cirrhosis,select the appropriate timing of surgery,and provide guidance for bridging treatment for patients on the waiting list for liver transplantation.Besides,HVPG may also predict clinical prognosis of liver transplant recipients,and provide evidence for early detection and intervention of potential complications.Therefore,the value of HVPG in preoperative evaluation and prognosis prediction of liver transplant recipients was reviewed,aiming to provide guidance for clinical diagnosis and treatment of liver transplant recipients before and after surgery.

关 键 词：肝静脉压力梯度 终末期肝病模型 肝移植 肝硬化 门静脉高压 食管-胃底静脉曲张 经颈静脉肝内门体静脉分流术 丙型肝炎病毒 

分 类 号：R617[医药卫生—外科学] R657.3[医药卫生—临床医学]