碳纤维离子化质谱技术的研究与应用  

Research and Application of Carbon Fiber Ionization Mass Spectrometry

作　　者：孔然 向平 陈卓南 赵君博 KONG Ran;XIANG Ping;CHEN Zhuo-nan;ZHAO Jun-bo(Shanghai Key Laboratory of Forensic Medicine,Shanghai Forensic Service Platform,Department of Forensic Toxicology,Shanghai 200063,China;School of Pharmacy,Yantai University,Yantai 264005,China)

机构地区：[1]上海市法医学重点实验室,上海市法医学服务平台,法医学毒理学研究室,上海200063 [2]烟台大学药学院,山东烟台264005

出　　处：《分析测试学报》2023年第1期116-123,共8页Journal of Instrumental Analysis

基　　金：上海市青年科技英才扬帆计划资助项目(21YF1448600);毒品监测管控与禁毒关键技术公安部重点实验室资助项目(2021-KLDMC-05);“科技创新行动计划”科学仪器领域资助项目(22142201500)。

摘　　要：碳纤维离子化技术是一种新型敞开式质谱技术,可在开放式大气压环境下对各种形态的样品或样品表面物质进行检测,其分析成本低、通量高、简便、实时、快速,简化了工作流程,降低了样品的基质效应。该文从碳纤维离子化质谱技术的原理出发,介绍了影响其电离效率的主要因素,如碳纤维形态、碳纤维温度、碳纤维上所加电压、碳纤维与离子进样口的距离以及样品添加的方式,并对该技术近几年的改进和发展,及其在食品药品、法医毒物及生物样品、品种鉴别和环境分析等领域的应用进行了综述,详细介绍了其特点和优势。最后讨论了碳纤维离子化质谱技术存在的不足,以及未来可能的研究方向。Carbon fiber ionization technology is a new kind of ambient ionization mass spectrometry technology,which could be used for detection on various forms of samples or sample surface material in open environment.This technology could simplify the work flow,reduce the matrix effect of samples and expand its application with the advantages of low cost,high throughput,simplicity,real time and rapidness.The main factors affecting the ionization efficiency,such as carbon fiber shape,carbon fiber temperature,voltage applied to carbon fiber,distance between carbon fiber and ion injection port,and sample adding method are introduced in this paper,based on the principle of carbon fiber ionization mass spectrometry technology.Furthermore,the improvement and development of the technology in recent years,and its application in the food and drug safety,forensic toxicology test,species identification and biological samples and environmental analysis are summarized,and the applications of the characteristics and advantages of this technology are introduced in detail.Finally,the existing shortcomings and future research directions of carbon fiber ionization mass spectrometry are discussed.

关 键 词：敞开式质谱 碳纤维离子化质谱技术 碳纤维离子化质谱技术的原理 影响因素 应用 

分 类 号：O657.6[理学—分析化学] TQ342[理学—化学]