常见益生菌耐药性研究进展  

Research progress on drug resistance of common probiotics

作　　者：吉星 李俊 王冉[1] 何涛[1] JI Xing;LI Jun;WANG Ran;HE Tao(Jiangsu Key Laboratory for Food Quality and Safety-State Key Laboratory Cultivation Base of Ministry of Science and Technology/Institute of Food Safety and Nutrition,Jiangsu Academy of Agricultural Sciences,Nanjing 210014,China)

机构地区：[1]江苏省农业科学院农产品质量安全与营养研究所/省部共建国家重点实验室培育基地——江苏省食品质量安全重点实验室,江苏南京210014

出　　处：《江苏农业学报》2022年第6期1722-1728,共7页Jiangsu Journal of Agricultural Sciences

基　　金：江苏省自然科学基金项目(BK20220746、BK20200056);江苏省农业科技自主创新基金项目[CX(22)3003]。

摘　　要：益生菌被定义为一种活的微生物,当摄入足够的量时,可在营养、新陈代谢和免疫功能等方面为宿主带来健康益处。益生菌目前被广泛应用在食品加工,医疗保健和畜禽养殖业,且市场正在扩大。益生菌的广泛使用可能带来新的风险,如成为耐药基因储存库并参与耐药基因的转移和扩散。基于公共卫生和食品安全的要求,本文对常用益生菌的种类、耐药表型测试方法、耐药特征及耐药基因转移情况进行了综述,为未来益生菌的安全规范管理和使用提供理论依据。Probiotics are defined as living micro-organisms that can bring health benefits to the host in terms of nutrition, metabolism and immune function when ingested in sufficient quantities. Probiotics are widely used in food processing, health care and livestock breeding, and the market is expanding. The widespread use of probiotics may bring new risks, such as becoming a reservoir of resistance genes and participating in the transfer and diffusion of drug resistance genes. Based on the requirements of public health and food safety, this paper reviewed the types, drug-resistance test methods, drug resistance characteristics, and drug-resistance gene transfer of commonly used probiotics, so as to provide a theoretical basis for the safe and standardized management and use of probiotics in the future.

关 键 词：益生菌 耐药性 耐药基因转移 

分 类 号：Q939.9[生物学—微生物学]