福建省近十年药物性肝损伤不良反应特征分析  

Characteristics of Drug-Induced Liver Injury in Fujian Province in Recent Ten Years

作　　者：张全超 蔡陈超 刘江龙 沈煜楠 阳丽梅 ZHANG Quan-chao;CAI Chen-chao;LIU Jiang-long;SHEN Yu-nan;YANG Li-mei(School of Basic Medical Sciences of Fujian Medical University,Fuzhou 350000,China;Department of Pharmacy,Provincial Clinical College of Fujian Medical University/Fujian Provincial Hospital,Fuzhou 350001,China)

机构地区：[1]福建医科大学基础医学院,福建福州350000 [2]福建医科大学省立临床医学院/福建省立医院药学部,福建福州350001

出　　处：《海峡药学》2022年第12期155-160,共6页Strait Pharmaceutical Journal

基　　金：福建省卫生健康中青年骨干人才培养项目(编号2019-ZQN-34);福建医科大学大学生创新创业训练计划项目(项目编号C21081)。

摘　　要：目的分析福建省近十年药物性肝损伤(DILI)的病例特点,为DILI的发病特点、诊疗、以及指南修订提供参考。方法从福建省不良反应监测中心数据库中检索2011年1月~2020年12月的7777例DILI患者的数据,采用回顾性分析,根据患者不同年龄、性别、地区、可疑药物等进行分组,分析DILI的病例特点。结果在7777例DILI病例中,男4467例(57.4%),女3310例(42.6%)。患者平均年龄(51.1±18.9)岁,以50~60岁最多。DILI上报例数与占比逐年上升;地区分布上,以福州市、厦门市、泉州市的患者上报比例最多。可疑药物以抗肿瘤药最多(占21.5%),其次分别为抗结核药(16.9%)、抗菌药物(15.0%)、调血脂药(11.5%)、抗精神分裂药(4.4%),与其他省份上报情况相比,中枢神经系统用药和中药明显偏少,抗肿瘤药物和抗心血管药物中的调血脂药物明显偏高。结论福建省DILI病例男性多于女性,抗肿瘤药所致的DILI发生率最高,发病年龄以50~60岁居多,临床上应引起足够重视。OBJECTIVE To analyze the characteristics of drug-induced liver injury(DILI)cases in Fujian Province in the past ten years,to provide references for the incidence,diagnosis,treatment of DILI.METHODS From the database of the Fujian Provincial Adverse Reaction Monitoring Center,we collected 7777 patients with DILI from 2011 to 2021.Retrospective analysis was used according to different ages,genders,regions,and suspicious drugs.RESULTS Among the 7777 patients with DILI,4467 were males(57.4%)and 3310 females(42.6%).The mean age of patients was(51.1±18.9)years old,most of which were 50-60 years old.The number and proportion of DILI increased yearly in the past 10 years.According to regional distribution,the report proportion in Fuzhou,Xiamen,and Quanzhou was particularly prominent.According to medications,anti-tumor drugs were the most suspected drugs(21.5%),followed by antituberculosis drugs(16.9%),antibiotics(15.0%),lipid-regulating drugs(11.5%)and antischizophrenia drugs(4.4%),respectively.Compared to other regional distribution,the central nervous system drugs and traditional Chinese medicine were significantly less,and the blood lipid regulating drugs in anti-tumor drugs and anti cardiovascular drugs were significantly higher.CONCLUSION Patients with DILI were more in males than females in Fujian province,and the incidence of DILI caused by anti-tumor drugs was the highest,with the majority of patients aged 50-60 years old,which should be paid more attention to.

关 键 词：药物性肝损伤 可疑药物 临床特征 合理用药 回顾性分析 

分 类 号：R969.4[医药卫生—药理学]