Electrochemical Ring Expansion to Synthesize Medium-Sized Lactams Through C–C Bond Cleavage  

作　　者：Kun Liu Chunlan Song Xu Jiang Xin Dong Yuqi Deng Wenxu Song Yanpei Yang Aiwen Lei 

机构地区：[1]College of Chemistry and Molecular Sciences,Institute for Advanced Studies(IAS),Wuhan University,Wuhan 430072 [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Shanghai 230021

出　　处：《CCS Chemistry》2021年第8期2236-2247,共12页中国化学会会刊（英文）

基　　金：the National Natural Science Foundation of China(no.21520102003);the Hubei Province Natural Science Foundation of China(no.2017CFA010);the Program of Introducing Talents of Discipline to Universities of China(111 Program)for their generous financial support.

摘　　要：Medium-sized nitrogen heterocycles are prevalent motifs in many kinds of bioactive molecules and natural products.Owing to the unfavorable enthalpic and entropic barriers during the transition states,access to medium-sized rings is challenging.Herein,a general and practical electrochemical ringexpansion protocol has been developed from commercially available benzocyclic ketones and amides.In this regard,a series of highly functionalized eightto eleven-membered lactams could be successfully accessed in high yields and efficiencies.

关 键 词：ELECTROCHEMISTRY medium-sized lactam ring expansion C–C bond cleavage nitrogen radical 

分 类 号：O62[理学—有机化学]