大剂量雷贝拉唑胃食管反流病(GERD)非典型症状的改善效果研究  

Study on the improvement of atypical symptoms of high-dose rabeprazole gastroesophageal reflux disease(GERD)

作　　者：扈建强 Hu Jianqiang(Department of Gastroenterology,Linxia Hui Autonomous Prefecture Maternal and Child Health Hospital,Linxia,Gansu,731100,China)

机构地区：[1]临夏回族自治州妇幼保健院,甘肃临夏731100

出　　处：《中国医学文摘（耳鼻咽喉科学）》2022年第6期20-22,3,共4页Chinese Medical Digest(Otorhinolaryngology)

摘　　要：目的探究大剂量雷贝拉唑对胃食管反流病非典型症状的改善效果。方法研究对象选取我院2019年1月至2020年1月期间收治入院的胃食管反流病非典型症状患者120例,根据随机数字法将患者均分为观察组和对照组,各60例。对照组患者给予常规剂量治疗,观察组患者给予大剂量治疗。比较两组患者治疗前及治疗8周后的症状评分及治疗有效率;比较两组患者治疗前、治疗4周及治疗8周对生活质量Likert评分结果;比较两组患者治疗满意度。结果在治疗8周后症状评分均较治疗前明显改善,观察组改善效果更加明显;观察组患者有效率显著高于对照组;治疗4周后两组患者Likert评分均显著降低;治疗8周后两组Likert评分进一步降低,显著低于治疗4周,且观察组显著低于对照组;观察组患者满意度显著高于对照组。结论大剂量雷贝拉唑治疗胃食管反流病非典型症状的改善效果显著,患者满意度高。Objective To explore the effect of high-dose rabeprazole on atypical symptoms of gastroesophageal reflux disease.Methods A total of 120 patients with atypical symptoms of gastroesophageal reflux disease admitted to our hospital from January 2019 to January 2020 were randomly divided into observation group(n=60)and control group(n=60).The patients in the control group were given routine dose treatment,and the patients in the observation group were given high dose treatment.The symptom scores and effective rates of the two groups before and 8 weeks after treatment were compared;the Likert scores of quality of life before treatment,4 weeks and 8 weeks after treatment were compared between the two groups;and the treatment satisfaction of the two groups were compared.Results After 8 weeks of treatment,the symptom scores were significantly improved compared with those before treatment,and the improvement effect of the observation group was more obvious;the effective rate of the observation group was significantly higher than that of the control group;the Likert scores of the two groups decreased significantly after 4 weeks of treatment;the Likert scores of the two groups further decreased after 8 weeks of treatment,which was significantly lower than that of the control group,and the patient satisfaction of the observation group was significantly higher than that of the control group.Conclusion High-dose rabeprazole is effective in the treatment of atypical symptoms of gastroesophageal reflux disease.

关 键 词：雷贝拉唑 反流性食管炎 不典型症状 Likert评分 

分 类 号：R47[医药卫生—护理学]