补肾益智方治疗阿尔兹海默病的研究进展  

Bushen Yizhi Formula in Treatment of Alzheimer’s Disease:A Review

作　　者：曾鹏 叶朝媛 苏泓妃 田青[2] ZENG Peng;YE Chaoyuan;SU Hongfei;TIAN Qing(School of Basic Medical Sciences,Hengyang Medical School,University of South China,Hengyang 421001,China;School of Basic Medicine,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]南华大学衡阳医学院基础医学院,湖南衡阳421001 [2]华中科技大学同济医学院基础医学院,武汉430030

出　　处：《中国实验方剂学杂志》2023年第1期270-282,共13页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金面上项目(82071478);湖北省卫生健康委中医药科研项目(面上ZY2021M041)。

摘　　要：阿尔茨海默病(AD)是最常见的痴呆形式,目前缺少疾病修饰性的治疗药物。中医理论认为肾精亏虚是AD发生发展的内在机制,补肾益精是中医治疗AD的基本原则,贯穿AD治疗的始终。补肾益智方是治疗AD的临床经验方。补肾益智方治疗AD已有大量文献报道,但补肾益智方缺乏临床应用安全性评价,同时其基础研究薄弱,有效成分不明、多靶点作用机制不清。为阐明补肾益智方多成分、多靶点、多途径治疗AD的作用机制,该文综述了补肾益智方治疗AD的研究进展。进一步收集了16个基于高效液相色谱指纹图谱的补肾益智方主要化学成分,并对其成药性与安全性进行评价。利用基于AD重要病理生理学过程的网络药理学与文献综述相结合的方法,深入分析了补肾益智方靶向胆碱能系统、AD神经病理学特征的有效成分及可能机制。该研究为AD对症治疗、疾病修饰性治疗的药物研发提供了一系列有潜力的先导化合物,并为深入拓展补肾益智方的临床应用提供了理论依据。Alzheimer’s disease(AD)is the most common form of dementia,and disease-modifying treatments are currently lacking.In traditional Chinese medicine(TCM),it is believed that kidney-essence deficiency is the internal mechanism of AD,and invigorating kidney and nourishing essence is the basic principle of TCM treatment of AD,which runs through the whole treatment process.Bushen Yizhi formula is a prescription for the treatment of AD,with rich experience in clinical practice.There have been massive literature reports on the treatment of AD with Bushen Yizhi formula,but its clinical safety is seldom studied,and its basic research is weak,with the active components and multi-target mechanism unclear.To clarify the mechanism of Bushen Yizhi formula in the treatment of AD with multiple components,targets and pathways,this paper summarized the research progress of Bushen Yizhi formula in the treatment of AD.We further collected 16 main chemical components of Bushen Yizhi formula based on HPLC fingerprints,and evaluated their druggability and safety.By combining network pharmacology and literature review on the important pathophysiological process of AD,we analyzed the active components and possible mechanisms of Bushen Yizhi formula targeting the cholinergic system and neuropathological characteristics of AD.This paper provided potential lead compounds for AD drug research and development,and a theoretical basis for the clinical application of Bushen Yizhi formula.

关 键 词：阿尔茨海默病 补肾益智方 病理生理学过程 化学成分 先导化合物 

分 类 号：R285[医药卫生—中药学] R289[医药卫生—中医学] R22R2-031R33