基于血小板与白细胞相互作用探讨活血解毒药干预心力衰竭的作用机制研究进展  

Research progress on the mechanism of activating blood circulation and detoxicating in the intervention of heart failure based on platelet-leukocyte interaction

作　　者：李琳 唐家杨[1] 魏小棋 于江 郭淑贞 LI Lin;TANG Jia-yang;WEI Xiao-qi;YU Jiang;GUO Shu-zhen(School of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;Beijing Institute of Traditional Chinese Medicine,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China)

机构地区：[1]北京中医药大学中医学院,北京100029 [2]首都医科大学附属北京中医医院,北京市中医药研究所,北京100010

出　　处：《中华中医药杂志》2022年第11期6619-6622,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81922075)。

摘　　要：心力衰竭(HF)在全球造成了较高的病死率和经济负担,血小板与白细胞相互作用造成的炎症级联效应是HF发生与进展的关键因素,抗血小板与白细胞相互作用已成为当前研究的热点。中医认为,瘀血内阻、蕴久化毒、瘀毒互结、损伤血络是HF缠绵难愈的关键病机。HF治疗应活血与解毒并重。文章主要整理了血小板与白细胞相互作用诱发HF的机制和活血解毒中药以血小板和白细胞为靶点治疗HF的研究成果。Heart failure causes a high mortality and economic burden in the world.The inflammatory cascade effect caused by the interaction between platelet and leukocyte is the key factor in the occurrence and progression of heart failure,and the inhibition of the interaction between platelet and leukocyte has become a research hotspot.Traditional Chinese medicine supports that the key pathogenesis of lingering heart failure is the blood stasis,the accumulation of toxin,the interconnection of blood stasis and toxin,and the damage of blood collaterals.The treatment of heart failure should pay equal attention to promoting blood circulation and detoxification.The article mainly summarized the mechanism of the interaction between platelet and leukocyte to induce heart failure and the research results of traditional Chinese medicine in the treatment of heart failure through targeting platelets and leukocytes.

关 键 词：炎症反应 血小板 白细胞 相互作用 活血解毒 心力衰竭 机制 进展 

分 类 号：R285[医药卫生—中药学]